M0398

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone

elastase inhibitor, powder, ≥98% (TLC)

• Synonim(y): N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine chloromethylketone
• Wzór empiryczny (zapis Hilla): C₂₂H₃₅ClN₄O₇
• Numer CAS: 65144-34-5
• Masa cząsteczkowa: 502.99
• NACRES: NA.77
• PubChem Substance ID: 24896552
• UNSPSC Code: 12352202
• MDL number: MFCD00077136
• Beilstein/REAXYS Number: 6167019

Właściwości

• Nazwa produktu: N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, elastase inhibitor
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• mp: 159 °C
• solubility: methanol: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)CCl
• InChI: 1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1
• InChI key: PJGDFLJMBAYGGC-XLPNERPQSA-N

Opis

General description

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.

Application

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone has been used as an elastase specific inhibitor.[1]

Biochem/physiol Actions

Irreversible inhibitor of human leukocyte[2] and neutrophil[3] elastase.

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone acts as a competitive inhibitor of human leukocyte elastase (HLE).

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)