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I4032

Interleukin-21 from mouse

Name: Interleukin-21 from mouse
Brand: SIGMA
Price: 3110 PLN

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonim(y):

IL-21

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Gabaryty przesyłki	SKU	Dostępność	Cena netto
10 μg		Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności	3110,00 zł

Informacje o tej pozycji

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD03703112

3110,00 zł

Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności

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Właściwości

biological source

mouse

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

40-120 ng/mL ED₅₀

mol wt

predicted mol wt ~14.4 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

Q9ES17

storage temp.

−20°C

Gene Information

mouse ... Il21(60505)

Opis

Biochem/physiol Actions

IL-21 (interleukin-21) belongs to the IL-2 cytokine family. It is secreted by CD4⁺ T, natural killer (NK) and Th17 cells. IL-21 associates with IL-21 receptor and participates in B-cell proliferation, differentiation as well as apoptosis. It also promotes the cytotoxic activity of CD8⁺ T cells and natural killer cells.IL-21 plays a crucial role in the differentiation of follicular helper T cells. It also exhibits antitumor activity.[1][2] It is also involved in the activation of JAK-STAT (Janus kinase - signal transducer and activator of transcription), PI3K (phosphatidylinositol 3-kinase) and MAPK (mitogen activated protein kinase) pathways.[3]

IL-21 and its receptor have important roles in T and B cell proliferation and natural killer cell maturation.

IL-21 and its receptor have important roles in T and B cell proliferation and natural killer cell maturation. Human and mouse IL-21 share 57% amino acid identity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to induce proliferation of human N1186 T cells.

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Ta pozycja	I4026	I8523	I1896
Sigma-Aldrich I4032 Interleukin-21 from mouse	Sigma-Aldrich I4026 Interleukin-17 from mouse	Sigma-Aldrich I8523 Interleukin-12 from mouse	Sigma-Aldrich I1896 Interleukin-13 from mouse
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in E. coli
biological source mouse	biological source mouse	biological source mouse	biological source mouse
assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
Gene Information mouse ... Il21(60505)	Gene Information mouse ... Il17a(16171)	Gene Information mouse ... Il12a(16159), Il12b(16160)	Gene Information mouse ... Il13(16163)

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming.

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Nature medicine, 16(1), 123-128 (2009-12-22)

The B cell lymphoma-6 (Bcl-6) and Bcl-xL proteins are expressed in germinal center B cells and enable them to endure the proliferative and mutagenic environment of the germinal center. By introducing these genes into peripheral blood memory B cells and

Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5.

Ferenc A Scheeren et al.

PloS one, 6(4), e17189-e17189 (2011-04-29)

Fully human monoclonal antibodies directed against specific pathogens have a high therapeutic potential, but are difficult to generate. Memory B cells were immortalized by expressing an inducible active mutant of the transcription factor Signal Transducer and Activator of Transcription 5

Interleukin-21 enhances rituximab activity in a cynomolgus monkey model of B cell depletion and in mouse B cell lymphoma models.

Cecile M Krejsa et al.

PloS one, 8(6), e67256-e67256 (2013-07-05)

Rituximab, a monoclonal antibody targeting CD20 on B cells, is currently used to treat many subtypes of B cell lymphomas. However, treatment is not curative and response rates are variable. Recombinant interleukin-21 (rIL-21) is a cytokine that enhances immune effector

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
I4032-10UG	04061833856529

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