This product has not been tested for solubility in DMSO. However, other sources suggest that this compound can be solubilized in DMSO at approximately 10 mg/mL. This information has not been validated.
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I1656
Idarubicin hydrochloride
Topoisomerase II inhibitor, solid
Synonim(y):
(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione, 4-Demethoxydaunorubicin hydrochloride, DMDR, IMI-30, Idamycin
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 10 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1080,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C26H27NO9 · HCl
Numer CAS:
Masa cząsteczkowa:
533.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
260-990-7
MDL number:
Form:
solid
Quality level:
1080,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Idarubicin hydrochloride, solid
form
solid
Quality Level
originator
Johnson & Johnson
shipped in
wet ice
storage temp.
2-8°C
SMILES string
[H][C@@]1(C[C@@](O)(Cc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c12)C(C)=O)O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5
InChI
1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1
InChI key
XDXDZDZNSLXDNA-TZNDIEGXSA-N
Gene Information
human ... TOP2A(7153)
Application
Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
Biochem/physiol Actions
Topoisomerase II inhibitor
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Ta pozycja | |||
|---|---|---|---|
| form solid | form - | form solid | form solid |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| shipped in wet ice | shipped in - | shipped in - | shipped in - |
| originator Johnson & Johnson | originator - | originator - | originator - |
| Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) | Gene Information - | Gene Information - |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2 - Repr. 1B
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Produkty
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Jungwon Huh et al.
American journal of hematology, 87(10), 961-968 (2012-08-14)
Core binding factor (CBF) AML with the D816 C-KIT gene mutation demonstrate inferior treatment outcomes. However, the remaining cases without the D816 C-KIT mutation imply a requirement of more sophisticated dissection of the patients according to their prognosis. In this
Claude Gardin et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(3), 321-327 (2012-12-19)
Although standard chemotherapy remains associated with a poor outcome in older patients with acute myeloid leukemia (AML), it is unclear which patients can survive long enough to be considered as cured. This study aimed to identify factors influencing the long-term
Monica L Guzman et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(25), 16220-16225 (2002-11-27)
Acute myelogenous leukemia (AML) is typically a disease of stem progenitor cell origin. Interestingly, the leukemic stem cell (LSC) shares many characteristics with normal hematopoietic stem cells (HSCs) including the ability to self-renew and a predominantly G(0) cell-cycle status. Thus
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Is this soluble in DMSO, if yes then what conc.?
1 answer-
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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What is the mode of action for idarubicin?
1 answer-
Idarubicin is an intercalating analog of daunorubicin that interferes with nucleic acid synthesis. It is an anti-tumor antibiotic used in the treatment of leukemia.
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How is idarubicin used therapeutically?
1 answer-
Idarubicin is an antineoplastic drug used to treat AML (Acute Myeloid Leukemia). In addition this compound has also been used in the treatment of breast cancer, non-Hodgkin's lymphoma, and both acute nonlymphocytic and chronic myelogenous leukemias.
Helpful?
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What can be used to make a solution of Idarubicin hydrochloride, Product I1656?
1 answer-
We test the solubility of idarubicin hydrochloride at 20 mg/ml of methanol. Idarubicin hydrochloride is also slightly soluble in water (10 mg/ml water with slight heat) and slightly soluble in ethanol.
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