A8727

Antalarmin hydrochloride

≥98% (HPLC), solid, CRF1 antagonist

• Synonim(y): N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride
• Wzór empiryczny (zapis Hilla): C₂₄H₃₄N₄·HCl
• Numer CAS: 220953-69-5
• Masa cząsteczkowa: 415.01
• Numer MDL: MFCD05664721
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24724401
• NACRES: NA.77

Właściwości

• Nazwa produktu: Antalarmin hydrochloride, ≥98% (HPLC), solid
• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: solid
• warunki przechowywania: desiccated
• kolor: off-white
• rozpuszczalność: DMSO: >10 mg/mL
• temp. przechowywania: 2-8°C
• ciąg SMILES: Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
• InChI: 1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
• Klucz InChI: CGDGXEDXEXACKQ-UHFFFAOYSA-N

Opis

Zastosowanie

Antalarmin hydrochloride has been used:

• to study its effect on stress-induced tryptophan hydroxylase 2 activity[1]
• to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation[2][3]
• to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression[4]

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Działania biochem./fizjol.

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.[5]

Cechy i korzyści

This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)