F6750

Riboflavin 5′-monophosphate sodium salt hydrate

70-79% (fluorimetric)

• Synonim(y): FMN-Na, Flavin mononucleotide, Riboflavin 5′-phosphate sodium salt
• Wzór empiryczny (zapis Hilla): C₁₇H₂₀N₄NaO₉P · xH₂O
• Numer CAS: 130-40-5
• Masa cząsteczkowa: 478.33 (anhydrous basis)
• NACRES: NA.51
• PubChem Substance ID: 24894910
• eCl@ss: 34058005
• UNSPSC Code: 41106305
• MDL number: MFCD00150992
• Beilstein/REAXYS Number: 4106529
• Assay: 70-79% (fluorimetric)
• Biological source: non-animal source
• Form: powder
• Solubility: water: 50 mg/mL, orange
• Storage temp.: −20°C

Właściwości

• biological source: non-animal source
• Quality Segment: 200
• description: (Clear to hazy)
• assay: 70-79% (fluorimetric)
• form: powder
• solubility: water: 50 mg/mL, orange
• storage temp.: −20°C
• SMILES string: O.[Na+].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O)c2cc1C
• InChI: 1S/C17H21N4O9P.Na.H2O/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);;1H2/q;+1;/p-1/t11-,12+,14-;;/m0../s1
• InChI key: BHRVCJBIICJWTH-APQIITSESA-M

Opis

General description

Riboflavin 5′-monophosphate is a derivative of riboflavin, a water-soluble vitamin.[1]

Application

Riboflavin 5′-monophosphate is used as a substrate to study the specificity and kinetics of FMN phosphohydrolases. FMN is used to study molecular sensing based gene regulation by riboswitches.

Riboflavin 5′-monophosphate sodium salt hydrate has been used in the preparation of hypo-osmolar riboflavin formulation:

• to evaluate the riboflavin (RF) concentration and distribution in the corneal stroma
• to study corneal resistance to enzymatic digestion[2]
• as a photosensitizer to evaluate the efficacy and safety of photochemical corneal stiffening using ex vivo and in vivo rabbit eye models[3]

Biochem/physiol Actions

Riboflavin 5′-monophosphate (FMN) serves as a cofactor for flavoenzymes. It is used as a prosthetic group by oxidoreductase[4] (one and two-electron transfer) enzymes, also called flavoproteins, such as nicotinamide adenine dinucleotide (NADH) dehydrogenases, nitric oxide synthases, nitric oxide reductase, and nitrilotriacetate monooxygenases. These enzymes protect cells from oxidative stress and apoptosis. Any alteration in the levels of FMN caused due to abnormal riboflavin metabolism leads to mitochondrial dysfunction and diminished energy levels. This results in disorders related to riboflavin such as cataracts, neurodegenerative and cardiovascular diseases. FMN is associated with metabolic pathways of amino acids, fatty acids, and purines. It is involved in cellular growth and development mediated by the oxidation-reduction reaction.[1]

Analysis Note

Free Riboflavin: ≤6.0%
Riboflavin diphosphates: ≤6.0% (as riboflavin)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)