F0931

Factor Va human

Name: Factor Va human
Brand: SIGMA
Price: 3600 PLN

≥1500 units/mg protein

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50 μG

3600,00 zł

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Informacje o tej pozycji

UNSPSC Code:

12352202

NACRES:

NA.61

MDL number:

MFCD01093755

Form:

solution

Biological source:

human

Mol wt:

168 kDa

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biological source

human

Quality Level

200

form

solution

specific activity

≥1500 units/mg protein

mol wt

168 kDa

technique(s)

ligand binding assay: suitable

UniProt accession no.

P12259

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... F5(2153)

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Ta pozycja	219365	F0806	233490
Sigma-Aldrich F0931 Factor Va human	Sigma-Aldrich 219365 Coagulation Factor V, Human Plasma	Sigma-Aldrich F0806 Factor IX human	Sigma-Aldrich 233490 Coagulation Factor XII, Human Plasma
technique(s) ligand binding assay: suitable	technique(s) -	technique(s) ligand binding assay: suitable	technique(s) -
biological source human	biological source -	biological source human	biological source -
form solution	form liquid	form aqueous glycerol solution	form liquid
mol wt 168 kDa	mol wt -	mol wt 55 kDa	mol wt -
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
UniProt accession no. P12259	UniProt accession no. -	UniProt accession no. P00740	UniProt accession no. -

General description

Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex.

Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma.

Biochem/physiol Actions

Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths.

Factor Va serves as a receptor and positive effector of factor Xa. Hence it can efficiently help in the conversion of prothrombin to thrombin.

Physical form

Aqueous solution containing 50% (v/v) glycerol and 5mM CaCl₂

Other Notes

One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C.

View this factors role in the Coagulation Cascade

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

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Klasa składowania

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Less Common Congenital Disorders of Hemostasis

Consultative Hemostasis and Thrombosis, 60-78 (2013)

The factor V activation paradox

Orfeo T, et al.

The Journal of Biological Chemistry, 279(19), 19580-19591 (2004)

Cryo-EM structure of the prothrombin-prothrombinase complex.

Eliza A Ruben et al.

Blood, 139(24), 3463-3473 (2022-04-16)

The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa (fXa), the cofactor fVa, Ca2+ and phospholipids, activates the zymogen prothrombin to the protease thrombin. The reaction

Clotting factor deficiency in early trauma-associated coagulopathy.

Sandro B Rizoli et al.

The Journal of trauma, 71(5 Suppl 1), S427-S434 (2011-12-17)

Coagulopathic bleeding is a leading cause of in-hospital death after injury. A recently proposed transfusion strategy calls for early and aggressive frozen plasma transfusion to bleeding trauma patients, thus addressing trauma-associated coagulopathy (TAC) by transfusing clotting factors (CFs). This strategy

Cryo-EM structures of human coagulation factors V and Va.

Eliza A Ruben et al.

Blood, 137(22), 3137-3144 (2021-03-09)

Coagulation factor V (fV) is the precursor of fVa, which, together with fXa, Ca2+, and phospholipids, defines the prothrombinase complex and activates prothrombin in the penultimate step of the coagulation cascade. We solved the cryogenic electron microscopy (cryo-EM) structures of

Numer pozycji handlu globalnego

SKU	NUMER GTIN
F0931-50UG	04061838031051

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Factor Va human