The reconstituted product has a limited lifetime in solution. Long-term storage in solution should be avoided.
E7764
Endothelin 1
≥97% (HPLC), powder
Synonim(y):
ET-1
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Wybierz wielkość
10 μG
305,00 zł
50 μG
775,00 zł
0.1 MG
1430,00 zł
305,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C109H159N25O32S5
Numer CAS:
Masa cząsteczkowa:
2491.90
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
human
Przejdź do
Pomoc techniczna
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Pozwól nam pomócInChI
1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)/t56-,57-,64-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,86-,87-,88-/m0/s1
SMILES string
[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N4)C(C)C)C(=O)N[C@@H](Cc5cnc[nH]5)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc6c[nH]c7ccccc67)C(O)=O
InChI key
ZUBDGKVDJUIMQQ-ZTNLKOGPSA-N
biological source
human
assay
≥97% (HPLC)
form
powder
technique(s)
ELISA: suitable
color
white
solubility
1% acetic acid: >1 mg/mL, H2O: >1 mg/mL
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... EDN1(1906)
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Ta pozycja | |||
|---|---|---|---|
| assay ≥97% (HPLC) | assay - | assay - | assay ≥97% (HPLC) |
| technique(s) ELISA: suitable | technique(s) immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:250, radioimmunoassay: 1:25,000, western blot: suitable | technique(s) immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL | technique(s) - |
| biological source human | biological source mouse | biological source mouse | biological source - |
| form powder | form - | form buffered aqueous solution | form powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
General description
Endothelin-1 (ET-1) is synthesized and secreted by activated endothelial cells, and is a peptide with potent vasoconstrictor activity. It is a marker for activated or dysfunctional endothelial cells.[1] This peptide is one of the three isopeptides belonging to the endothelin family. It is also released by cardiomyocytes.[2]
Application
Endothelin-1 (ET-1) has been used to study the production and detection of H2O2 and production of NO in the presence of ET-1,[3] for studying the effects of ET-1 on the eNOS/inducible NOS (iNOS)/caveolin-1 expression, NO production, isoform specific PKC translocation, and PKC activity in human saphenous vein endothelial cells (HSVECs).[4]
Biochem/physiol Actions
Endothelin is a potent agonist for ETA and ETB endothelin receptors.
Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions.[1] ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer) cells.[5] The plasma levels of this peptide are increased in patients with atrial septal defect (ASD), and these levels might help in diagnosis of closure defects.[2] The plasma level of ET-1 is also higher in patients with end-stage renal disease (ESRD), and this is linked to gradual worsening of pulmonary function tests.[6]
Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
Other Notes
A synthetic peptide with the sequence of human and porcine Endothelin 1.
Lyophilized from 0.1% TFA in H2O
The biological source is human endothelin, which shares the same sequence
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related product
Numer produktu
Opis
Cennik
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Stephen Wedgwood et al.
American journal of physiology. Lung cellular and molecular physiology, 288(3), L480-L487 (2004-11-09)
Similar to infants born with persistent pulmonary hypertension of the newborn (PPHN), there is an increase in circulating endothelin-1 (ET-1) and decreased endothelial nitric oxide synthase (eNOS) gene expression in an ovine model of PPHN. These abnormalities lead to vasoconstriction
Hao-Jie Zhang et al.
Asian Pacific journal of cancer prevention : APJCP, 15(23), 10079-10083 (2015-01-06)
Endothelin-1 and Endostar are both significant for the progression, proliferation, metastasis and invasion of cancer. In this paper, we studied the effect of ET-1 RNAi and Endostar in PC-3 prostatic cancer cells. The lentiviral vector was used in the establishment
Monika Komar et al.
Cardiovascular ultrasound, 12, 31-31 (2014-08-08)
The study aimed to assess the level of plasma Endothelin-1 (ET-1) in patients before and after transcatheter closure of atrial septal defect (ASD) and to evaluate the usefulness of measuring ET-1 levels for the diagnosis and selection of candidates for
Javid Safa et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 25(4), 781-787 (2014-06-28)
End-stage renal disease (ESRD) is a complex illness that involves different organs including the lungs. We studied the pulmonary function tests, arterial blood gases (ABG) and plasma endothelin-1 (ET-1) levels to check whether there is any change in their levels
T Masaki et al.
European journal of pharmacology, 375(1-3), 133-138 (1999-08-12)
To elucidate the role of endothelin in the regulation of vascular function, the cellular and subcellular mechanisms for the synthesis of endothelin and the function of endothelin-receptors have been studied extensively. In this article, recent results regarding these problems are
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