The solubility of Ceftazidime hydrate (C3809) is as follows: it is soluble at 50mg/mL in 0.1 M NaOH.
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C3809
Ceftazidime hydrate
90.0-105.0%, contains ~10% sodium carbonate as stabilizer
Synonim(y):
1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 1 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 699,00 zł | |
| 5 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2360,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C22H22N6O7S2 · xH2O
Numer CAS:
Masa cząsteczkowa:
546.58 (anhydrous basis)
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51284108
MDL number:
699,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócQuality Level
assay
90.0-105.0%
form
powder or crystals
contains
~10% sodium carbonate as stabilizer
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].CC(C)(O\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[n+]3ccccc3)=C(N2C1=O)C([O-])=O)c4csc(N)n4)C(O)=O
InChI
1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1
InChI key
NMVPEQXCMGEDNH-TZVUEUGBSA-N
General description
Broad spectrum antibiotic; third generation cephalosporin
Chemical structure: β-lactam
Application
Ceftazidime hydrate is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis. It is also used in bacterial susceptibility studies and to select mutant colonies of interest.
Used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cephalosporins, such as ceftazidime , disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place
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Ta pozycja | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| assay 90.0-105.0% | assay 95.0-102.0% anhydrous basis | assay ≥98% (HPLC) | assay 90-102% anhydrous basis (HPLC) |
| form powder or crystals | form powder or crystals | form powder | form crystalline powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| contains ~10% sodium carbonate as stabilizer | contains - | contains - | contains - |
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Sens. 1
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Neang S Ly et al.
The Journal of antimicrobial chemotherapy, 70(5), 1434-1442 (2015-02-26)
Colistin is an 'old' drug, which is being increasingly utilized due to limited therapeutic options. However, resistance emergence during monotherapy is concerning. Here, our objective was to optimize colistin combinations against Pseudomonas aeruginosa by profiling the time course of synergistic
Kristopher R Genschmer et al.
Cell, 176(1-2), 113-126 (2019-01-12)
Here, we describe a novel pathogenic entity, the activated PMN (polymorphonuclear leukocyte, i.e., neutrophil)-derived exosome. These CD63+/CD66b+ nanovesicles acquire surface-bound neutrophil elastase (NE) during PMN degranulation, NE being oriented in a configuration resistant to α1-antitrypsin (α1AT). These exosomes bind and
Melissa D Barnes et al.
mBio, 9(6) (2018-12-13)
Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics. In response to this significant clinical threat, ceftolozane, a
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| C3809-1G | 04061833486436 |
| C3809-5G | 04061833486443 |
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What is the recommended method for reconstituting the product C3809, Ceftazidime hydrate?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solution stability of the Product C3809, Ceftazidime hydrate?
1 answer-
Unfortunately, we do not test Product C3809, Ceftazidime hydrate, for solution stability. However, Chedru-Legros V. et al., Cornea, 29(7),807-11(2010), report 5% solutions of ceftazidime 0.9% sodium chloride can be stored at -20°C for 6 months. Also, Mehta, S. et al., Retina, 31(7),1316-22 (2011), reports single-use polypropylene syringes retain potency, sterility, and stability for 24 weeks when stored at -20°C or -80°C.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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