SML0056

Cefotiam dihydrochloride hydrate

≥98% (HPLC)

• Synonim(y): (6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate
• Wzór empiryczny (zapis Hilla): C₁₈H₂₃N₉O₄S₃ · 2HCl · xH₂O
• Numer CAS: 66309-69-1
• Masa cząsteczkowa: 598.55 (anhydrous basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥22 M
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [s]1c(nc(c1)CC(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)CSc4[n](nnn4)CCN(C)C)N.[Cl-].[Cl-].[H+].[H+]
• InChI: 1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1
• InChI key: BWRRTAXZCKVRON-DGPOFWGLSA-N

Opis

General description

Chemical structure: β-lactam

Application

Cefotiam dihydrochloride hydrate is used as broad-spectrum antibiotic.

Biochem/physiol Actions

Cefotiam is a second generation cephalosporin antibiotic which has been used as a prophylatic antibiotic for MRSA.

Cefotiam, a derivative of cephalosporin, exhibits broad-spectrum anti-bacterial activity. It inhibits the cross-linking stage of peptidoglycan and blocks the synthesis of bacterial cell wall. It is resistant to β-lactamases.[1][2]

Second generation cephalosporin, prophylatic antibiotic for MRSA

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable