C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

Name: Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone
Brand: SIGMA
Price: 2200 PLN

≥90% (TLC), powder

Synonim(y):

Z-IETD-FMK

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1 MG

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₃₀H₄₃FN₄O₁₁

Numer CAS:

220760-26-9

Masa cząsteczkowa:

654.68

NACRES:

NA.77

PubChem Substance ID:

329774744

UNSPSC Code:

12352209

MDL number:

MFCD01861686

Assay:

≥90% (TLC)

Form:

powder

Quality level:

200

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Pozwól nam pomóc

biological source

synthetic (organic)

Quality Level

200

assay

≥90% (TLC)

form

powder

solubility

methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF

InChI

1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1

InChI key

CTXDBLYOEUERAT-VUVYEONESA-N

Powiązane kategorie

Bioactive Small Molecule Inhibitors

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Ta pozycja	C1480	C2105	B2682
Sigma-Aldrich C1230 Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone	Sigma-Aldrich C1480 Z-Phe-Ala fluoromethyl ketone	Sigma-Aldrich C2105 Z-Val-Ala-Asp fluoromethyl ketone	Sigma-Aldrich B2682 Boc-Asp(OMe)-fluoromethyl ketone
assay ≥90% (TLC)	assay ≥90% (TLC)	assay ≥90% (TLC)	assay ≥90% (TLC)
form powder	form powder	form powder	form solid
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow	solubility DMSO or DMF: 20 mM	solubility -	solubility DMF: soluble
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in -

Application

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

to study the activity of caspase-8 in porcine kidney cells[1]
to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells[2]
to study its effects on retinal ganglion and astroglia in rat eyes[3]

Biochem/physiol Actions

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.[4]

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Study of caspase inhibitors for limiting death in mammalian cell culture.

Tina M Sauerwald et al.

Biotechnology and bioengineering, 81(3), 329-340 (2002-12-11)

Apoptosis in mammalian cell culture is associated with decreased bioproduct yields and can be inhibited through altering the intracellular signaling pathways mediating programmed cell death. In this study, we evaluated the capacity to inhibit caspases to maintain high viable cell

PLF-1 (Proliferin-1) Modulates Smooth Muscle Cell Proliferation and Development of Experimental Intimal Hyperplasia.

Lina Hu et al.

Journal of the American Heart Association, 8(24), e005886-e005886 (2019-12-17)

Background Although apoptosis and cell proliferation have been extensively investigated in atherosclerosis and restenosis postinjury, the communication between these 2 cellular events has not been evaluated. Here, we report an inextricable communicative link between apoptosis and smooth muscle cell proliferation

CUL7 promotes cancer cell survival through promoting Caspase-8 ubiquitination.

Yanjie Kong et al.

International journal of cancer, 145(5), 1371-1381 (2019-02-27)

The Cullin 7 (CUL7) gene encodes a member of the cullin family of E3 ubiquitin ligases. Accumulated evidence suggests that CUL7 is oncogenic. However, the mechanism by which CUL7 improves cancer cell survival has not been fully elucidated. Here, we

HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-Gp120 aptamer.

Walter R Lopes de Campos et al.

PloS one, 9(10), e110930-e110930 (2014-10-21)

HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART). For these reasons, we investigated the direct and indirect effects of HIV-1

Autoamplificatory singlet oxygen generation sensitizes tumor cells for intercellular apoptosis-inducing signaling.

Georg Bauer

Mechanisms of ageing and development, 172, 59-77 (2017-11-16)

Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase. of tumor cells with high concentrations of H2O2, peroxnitrite, HOCl, or increasing the

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
C1230-1MG	04061833461952

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Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone