B1401

Bradykinin Fragment 1-5

Name: Bradykinin Fragment 1-5
Brand: SIGMA
Price: 499 PLN

≥97% (HPLC)

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1 MG

499,00 zł

5 MG

1710,00 zł

499,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₇H₄₀N₈O₆

Numer CAS:

23815-89-6

Masa cząsteczkowa:

572.66

NACRES:

NA.32

PubChem Substance ID:

24891591

UNSPSC Code:

12352200

MDL number:

MFCD00076260

Form:

powder

Assay:

≥97% (HPLC)

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InChI

1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)

SMILES string

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O

InChI key

USSUMSBPLJWFSZ-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

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Ta pozycja	B1901	I3400	K1632
Sigma-Aldrich B1401 Bradykinin Fragment 1-5	Sigma-Aldrich B1901 Bradykinin Fragment 2-9	Sigma-Aldrich I3400 Interferon-γ-Inducible Protein-10 human	Sigma-Aldrich K1632 Kininogen high molecular weight, Two Chain from human plasma
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (SDS-PAGE)	assay -
form powder	form powder	form lyophilized powder	form lyophilized powder
Gene Information human ... KNG1 (includes EG:3827)(3827)	Gene Information human ... KNG1 (includes EG:3827)(3827)	Gene Information human ... CXCL10(3627)	Gene Information human ... KNG1(3827), KNG1 (includes EG:3827)(3827)
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
UniProt accession no. P01042	UniProt accession no. P01042	UniProt accession no. P01579	UniProt accession no. P01042
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Odwiedź Bibliotekę dokumentów

A daughter of bradykinin that protects against septicaemia.

S A Doggrell

Expert opinion on investigational drugs, 10(8), 1567-1569 (2002-01-12)

When the defence response of the body to infectious bacteria fails, septic shock ensues with hypotension and death. RPPGF,(1-5)-bradykinin, was until recently considered to be an active metabolite of bradykinin. In an animal model of septicaemia (lipopolysaccharide administration to rats)

Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass.

Mias Pretorius et al.

Clinical pharmacology and therapeutics, 76(4), 379-387 (2004-10-08)

This study tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitors potentiate activation of the kallikrein-kinin system during cardiopulmonary bypass (CPB). The effects of CPB on concentrations of bradykinin and its metabolite bradykinin 1-5 (BK1-5) were determined in 31 patients taking

Blockade of bradykinin B(2) receptor suppresses acute pancreatitis induced by obstruction of the pancreaticobiliary duct in rats.

Mitsuhiro Hirata et al.

British journal of pharmacology, 135(1), 29-36 (2002-01-12)

1. The involvement of bradykinin (BK) B(2) receptor in acute pancreatitis induced by pancreaticobiliary duct ligation was investigated in rats. 2. The activities of amylase and lipase in the serum, the water content of the pancreas, and vacuolization of the

Metabolism of bradykinin in aorta of hypertensive rats.

Beata Bujak-Giżycka et al.

Acta biochimica Polonica, 58(2), 199-202 (2011-05-31)

Alterations in the formation and metabolism of bradykinin (Bk) are hypothesized to play a role in the pathophysiology of hypertension, atherosclerosis and vascular complications of diabetes. However, despite its prominent role in cardiovascular regulation, studies on bradykinin have been limited

A metabolic fragment of bradykinin, Arg-Pro-Pro-Gly-Phe, protects against the deleterious effects of lipopolysaccharide in rats.

T A Morinelli et al.

The Journal of pharmacology and experimental therapeutics, 296(1), 71-76 (2000-12-21)

Extensive research has provided few therapeutic agents for the treatment of septicemia. Bradykinin, an endogenous vasodepressor hormone, is a key mediator in the hypotension seen with septicemia. The present investigation shows that a stable metabolic fragment of bradykinin, arginine-proline-proline-glycine-phenylalanine (RPPGF)

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Bradykinin Fragment 1-5