The solubility information can be found on the Specification sheet: Solubility (Solvent) Water or 1% Acetic Acid Solubility (Conc) 1.00 - 1.04 mg/ml. Stock solutions are stable for up to 3 months at -20°C.
A1439
Pituitary adenylate cyclase activating polypeptide-38
Synonim(y):
PACAP-38
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Wybierz wielkość
0.1 MG
1610,00 zł
1610,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C203H331N63O53S
Numer CAS:
Masa cząsteczkowa:
4534.26
UNSPSC Code:
41106305
NACRES:
NA.32
MDL number:
Form:
powder
Quality level:
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Pozwól nam pomócform
powder
Quality Level
composition
Peptide content, ~70%
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... ADCYAP1(116)
1 of 4
Ta pozycja | |||
|---|---|---|---|
| form powder | form lyophilized powder | form lyophilized powder | form lyophilized |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| composition Peptide content, ~70% | composition - | composition - | composition - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. |
| Gene Information human ... ADCYAP1(116) | Gene Information bovine ... FGF2(281161) | Gene Information - | Gene Information mouse ... Il1f10(215274) |
General description
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is mapped to human chromosome 18. 27-residue-amidated fragment (PACAP27) comprises another isoform. The PACAP38 is major isoform associated with mammals.[1]
Application
Biochem/physiol Actions
PACAP-38 is a neuropeptide that has substantial sequence homology to vasoactive intestinal peptide (VIP). It is reported to serve as a neuronal survival factor.
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a cardioprotectant and may help in treating radiation-induced heart disease (RIHD). It plays a protective role during oxidative stress in cardiomyocytes. PACAP38 has antioxidant, anti-apoptotic and anti-inflammatory property.[4] It is implicated in the pathophysiology of migraine and cluster headache.[5]
Other Notes
Lyophilized from 0.1% TFA in H2O
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Bernadett Tuka et al.
The journal of headache and pain, 17(1), 69-69 (2016-08-01)
Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and
A J Martínez-Fuentes et al.
Endocrinology, 139(12), 5116-5124 (1998-12-01)
We have recently shown that the two bioactive forms of pituitary adenylate cyclase-activating polypeptide, PACAP38 and PACAP27, stimulate GH release and GH messenger RNA (mRNA) accumulation in cultured porcine pituitary cells. However, dose- and time-related differences in the response to
E M Lutz et al.
British journal of pharmacology, 128(4), 934-940 (1999-11-11)
1 The VPAC2 and PAC1 receptors are closely related members of the Group II G protein-coupled receptor family. At the VPAC2 receptor, VIP is equipotent to PACAP-38 in stimulating cyclic AMP production, whereas at the PAC1 receptor PACAP-38 is many
Grazia Maugeri et al.
Frontiers in pharmacology, 7, 139-139 (2016-06-16)
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma multiforme (GBM). This tumor is characterized by extensive areas of
K Tornøe et al.
American journal of physiology. Endocrinology and metabolism, 279(6), E1413-E1425 (2000-11-30)
The concentration of pituitary adenylyl cyclase-activating polypeptide [PACAP-(1-38)] in porcine adrenal glands amounted to 14 +/- 3 pmol/g tissue. PACAP immunoreactive (PACAP-IR) fibers innervated adrenal chromaffin cells (often co-localized with choline acetyltransferase). Subcapsular fibers traversed the cortex-innervating endocrine cells and
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| A1439-.1MG | 04061833342343 |
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How can stock solutions for item A1439, Pituitary adenylate cyclase activating polypeptide-38, be reconstituted and stored?
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