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Merck

74667

Nourseothricin sulfate

≥85% (HPLC)

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Wybierz wielkość

10 MG

1220,00 zł

100 MG

8350,00 zł

1220,00 zł


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Informacje o tej pozycji

Numer CAS:
UNSPSC Code:
51102829
NACRES:
NA.85
MDL number:

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Pomoc techniczna
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Pozwól nam pomóc

biological source

Streptomyces noursei

Quality Level

assay

≥85% (HPLC)

form

solid

color

white to light brown

solubility

H2O: soluble 200 mg/mL

suitability

suitable for (selection agent for molecular genetic research work)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, mycobacteria, mycoplasma, parasites, viruses, yeast

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(O)O.N4[C@H]5[C@H](N=C4N[C@@H]6O[C@@H]([C@@H]([C@H]([C@H]6NC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCN)O)OC(=O)N)CO)C(=O)NC[C@H]5O.N1[C@H]2[C@H](N=C1N[C@@H]3O[C@@H]([C@@H]([C@H]([C@H]3NC(=O)C[C@@H](N)CCCN)O)OC(=O)N)CO)C(=O)NC[C@H]

InChI key

HEPYPTBGGNPPAP-SPCBHCMPSA-N

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Ta pozycja
N0186N8028P9620
mode of action

protein synthesis | interferes

mode of action

-

mode of action

cell wall synthesis | interferes, enzyme | inhibits

mode of action

protein synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria, fungi, mycoplasma, viruses, Gram-positive bacteria, parasites, mycobacteria, yeast

antibiotic activity spectrum

-

antibiotic activity spectrum

fungi

antibiotic activity spectrum

Gram-positive bacteria, neoplastics, parasites

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

300

suitability

suitable for (selection agent for molecular genetic research work)

suitability

-

suitability

-

suitability

-

assay

≥85% (HPLC)

assay

-

assay

≥90% (HPLC)

assay

>98% (HPLC)

form

solid

form

powder

form

powder

form

solution

General description

Chemical structure: peptidyl nucleoside

Application

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

Biochem/physiol Actions

Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.
Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.

Packaging

10mg, 100mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.
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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Adrian J Verster et al.
G3 (Bethesda, Md.), 7(10), 3337-3347 (2017-08-26)
Genes encoding essential components of core cellular processes are typically highly conserved across eukaryotes. However, a small proportion of essential genes are highly taxonomically restricted; there appear to be no similar genes outside the genomes of highly related species. What
Mojca Mattiazzi Usaj et al.
Molecular systems biology, 16(2), e9243-e9243 (2020-02-18)
Our ability to understand the genotype-to-phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single-cell level. To systematically assess cell-to-cell phenotypic variability, we combined automated yeast genetics, high-content screening and neural network-based image analysis of
Dorota Fennessy et al.
PloS one, 9(5), e97683-e97683 (2014-05-23)
Targeted alteration of the genome lies at the heart of the exploitation of S. pombe as a model system. The rate of analysis is often determined by the efficiency with which a target locus can be manipulated. For most loci
Chetan C Rawal et al.
Cell reports, 31(5), 107603-107603 (2020-05-07)
An important but still enigmatic function of DNA:RNA hybrids is their role in DNA double-strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the human helicase Senataxin, is recruited at an HO endonuclease-induced DSB and
Joan Castells-Ballester et al.
International journal of molecular sciences, 20(24) (2019-12-15)
O-mannosylation is implicated in protein quality control in Saccharomyces cerevisiae due to the attachment of mannose to serine and threonine residues of un- or misfolded proteins in the endoplasmic reticulum (ER). This process also designated as unfolded protein O-mannosylation (UPOM)

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Numer pozycji handlu globalnego

SKUNUMER GTIN
74667-10MG04061832891453
74667-100MG04061832891446

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