59983

Josamycin

≥90% (HPLC)

• Synonim(y): Leucomycin A3
• Wzór empiryczny (zapis Hilla): C₄₂H₆₉NO₁₅
• Numer CAS: 16846-24-5
• Masa cząsteczkowa: 827.99
• Numer WE: 240-871-6
• Numer MDL: MFCD00211043
• Kod UNSPSC: 51102829
• Identyfikator substancji w PubChem: 57651709
• NACRES: NA.85

Właściwości

• Poziom jakości: 200
• Próba: ≥90% (HPLC)
• Postać: powder
• kolor: white to slightly yellow
• spektrum działania antybiotyku: Gram-positive bacteria
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: 2-8°C
• ciąg SMILES: CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)OC(C)=O
• InChI: 1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1
• Klucz InChI: XJSFLOJWULLJQS-NGVXBBESSA-N

Opis

Opis ogólny

Chemical structure: macrolide

Zastosowanie

Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

Działania biochem./fizjol.

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)