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70990

α-Cyano-4-hydroxycinnamic acid

suitable for matrix substance for MALDI-MS, ≥99.0% (HPLC)

Synonim(y):

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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Do Państwa/SKUDostępnośćCena netto
250 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
211,00 zł
1 g
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527,00 zł

Informacje o tej pozycji

Wzór liniowy:
HOC6H4CH=C(CN)CO2H
Numer CAS:
Masa cząsteczkowa:
189.17
UNSPSC Code:
41115710
NACRES:
NA.21
PubChem Substance ID:
EC Number:
248-879-1
Beilstein/REAXYS Number:
3271427
MDL number:
Assay:
≥99.0% (HPLC)
Form:
solid

211,00 zł


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Quality Segment

assay

≥99.0% (HPLC)

form

solid

analyte chemical class(es)

glycans, peptides, proteins

technique(s)

MALDI-MS: suitable

mp

245-250 °C

solubility

methanol: 10 mg/mL, clear

cation traces

Ba: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, K: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤10 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

absorption

≥2000 at 337 nm (mol. absorption)

suitability

suitable for matrix substance for MALDI-MS

SMILES string

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

General description

α-Cyano-4-hydroxycinnamic acid (α-CHCA) is widely used as a matrix in order to facilitate ionization of peptides and proteins in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer.[1]

Application

α-CHCA was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF.[1]

Other Notes

Matrix substoncitatioance used in MALDI-MS (matrix-assisted laser desorption ionization MS) peptide analysis in proteomics.
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Ta pozycja
39468C8982145505
form

solid

form

solid

form

powder

form

powder

assay

≥99.0% (HPLC)

assay

-

assay

-

assay

97%

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

technique(s)

MALDI-MS: suitable

technique(s)

MALDI-MS: suitable

technique(s)

-

technique(s)

-

solubility

methanol: 10 mg/mL, clear

solubility

methanol: 10 mg/mL, clear

solubility

-

solubility

methanol: soluble 50 mg/mL, clear to slightly hazy, light yellow to yellow

cation traces

Ba: ≤5 mg/kg, Cd: ≤5 mg/kg, Cr: ≤5 mg/kg, K: ≤5 mg/kg, Mn: ≤5 mg/kg, Ni: ≤5 mg/kg, Zn: ≤5 mg/kg, Ca: ≤10 mg/kg, Cu: ≤5 mg/kg, Na: ≤10 mg/kg, Co: ≤5 mg/kg, Pb: ≤5 mg/kg, Mg: ≤5 mg/kg

cation traces

Al: ≤1 mg/kg, Ba: ≤1 mg/kg, Ca: ≤1 mg/kg, Cd: ≤1 mg/kg, Co: ≤1 mg/kg, Cr: ≤1 mg/kg, Cu: ≤1 mg/kg, Fe: ≤1 mg/kg, K: ≤1 mg/kg, Li: ≤1 mg/kg, Mg: ≤1 mg/kg, Mn: ≤1 mg/kg, Na: ≤1 mg/kg, Ni: ≤1 mg/kg, Pb: ≤1 mg/kg, Sr: ≤1 mg/kg, Zn: ≤1 mg/kg

cation traces

-

cation traces

-


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1B

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Questions

1–6 of 6 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?

    1 answer
    1. α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.

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  4. What is the shelf life of Product 70990, α-Cyano-4-hydroxycinnamic acid?

    1 answer
    1. This product does not have an Expiration or Recommended Re-Test date established for it.  As with all Sigma-Aldrich products, it is guaranteed up to a year from date of shipment.

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  5. What is the appearance of Product 70990, α-Cyano-4-hydroxycinnamic acid?

    1 answer
    1. Catalog number 70990 is a powder, and has an appearance specification of faintly yellow to yellow in color.

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  6. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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