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AB10518

Sigma-Aldrich

Anti-DARPP-32 Antibody

from rabbit, purified by affinity chromatography

Synonim(y):

protein phosphatase 1, regulatory (inhibitor) subunit 1B, dopamine and cAMP-regulated neuronal phosphoprotein 32, dopamine and cAMP regulated phosphoprotein, protein phosphatase 1 regulatory subunit 1B, Dopamine- and cAMP-regulated neuronal phosphoprotei

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

100

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

oczyszczone przez

affinity chromatography

reaktywność gatunkowa

rat, mouse, rhesus macaque

reaktywność gatunkowa (przewidywana na podstawie homologii)

canine (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology)

metody

immunoprecipitation (IP): suitable
western blot: suitable

numer dostępu NCBI

NP_659077

numer dostępu UniProt

Q60829

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

mouse ... Ppp1R1B(19049)

Opis ogólny

Dopamine- and cAMP-regulated neuronal phosphoprotein (DARP-32) is a cytoplasmic member of the protein phosphatase inhibitor 1 family. DARP-32 is a multifunctional protein kinase and protein phosphatase regulator, depending on the site of its activation. It possesses at least four sites that can be phosphorylated. Phosphorylation by PKA at Thr34 stimulates DARP-32 to act as a protein-phosphatase-1 (PP-1) inhibitor. However, phosphorylation at Thr75 will inhibit Thr34 phosphorylation. This selective, bidirectional regulation allows DARPP-32 to have a wide range of influence on downstream physiological effectors such as: ion pumps, neurotransmitter receptors, voltage-gate ion channels, and transcriptional factors. Studies suggest that it may also have a role in the Circadian System photic pathway. Overexpression of DARPP-32 has been linked with antiapoptotic mechanisms of cancer cells and has been observed in breast, colon, esophagus, gastric, and prostate cancer tissues.

Specyficzność

This antibody recognizes DARPP-32 near the N-terminus.

Immunogen

KLH-conjugated linear peptide corresponding to mouse DARPP-32 near the N-terminus.

Zastosowanie

Anti-DARPP-32 Antibody is an antibody against DARPP-32 for use in WB & IP.
Research Sub Category
Neurotransmitters & Receptors

Ion Channels & Transporters
Western Blot (Snap i.d.) Analysis: 1 µg/mL of this antibody from a previous lot detected DARPP-32 on 10 µg of rat brain tissue lysate.

Immunoprecipitaion Analysis: 10 µg of this antibody from a previous lot immunoprecipitated DARPP-32 from rat brain RIPA lysate.

Jakość

Evaluated by Western Blot on rat brain tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected DARPP-32 on 10 µg of rat brain tissue lysate.

Opis wartości docelowych

~ 32 kDa observed

Powiązanie

Replaces: AB1656

Inne uwagi

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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