681674

Wnt Pathway Inhibitor XI, CCT036477

The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonim(y): Wnt Pathway Inhibitor XI, CCT036477, CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
• Wzór empiryczny (zapis Hilla): C₂₁H₁₈ClN₃
• Numer CAS: 305372-78-5
• Masa cząsteczkowa: 347.84
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01831143
• Assay: ≥95% (¹H-NMR)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Level: 100
• assay: ≥95% (¹H-NMR)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Clc1ccc(cc1)C(Nc4ncccc4)c2c3c([nH]c2C)cccc3
• InChI: 1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
• InChI key: IFOHRIXRQPOHQZ-UHFFFAOYSA-N

Opis

General description

A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC₅₀ = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.

Packaging

Packaged under inert gas

Preparation Note

Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ewan, K., et al. 2010. Cancer Res.70, 5963.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2