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681629

W-7, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).

Synonim(y):

W-7, Hydrochloride, N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 mg

Przewidywany termin wysyłki11 maja 2026zKuehne + Nagel Sp. z o.o.

596,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C16H21ClN2O2S · xHCl
Numer CAS:
61714-27-0
Masa cząsteczkowa:
340.87 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00012559
Assay:
≥98% (TLC)
Form:
crystalline solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

596,00 zł

Przewidywany termin wysyłki11 maja 2026Szczegóły

​
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Quality Level

100

description

RTECS - QK0786000

assay

≥98% (TLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

off-white

solubility

DMSO: 5 mg/mL, DMF: soluble, warm ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NCCCCCCN)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]

InChI

1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H

InChI key

OMMOSRLIFSCDBL-UHFFFAOYSA-N

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM) and myosin light chain kinase (IC50 = 51 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Myosin light chain kinase
Product does not compete with ATP.
Reversible: yes
Target IC50: 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase

Other Notes

Caulfield, M.P., et al. 1991. Neurosci. Lett.125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther.251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem.96, 1721.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)
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Ta pozycja
681625475880444200
W-7, Hydrochloride A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).

Sigma-Aldrich

681629

W-7, Hydrochloride

W-5, Hydrochloride A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).

Sigma-Aldrich

681625

W-5, Hydrochloride

ML-7, Hydrochloride A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).

Sigma-Aldrich

475880

ML-7, Hydrochloride

MDL-12,330A, Hydrochloride Cell-permeable and irreversible inhibitor of adenylate cyclase (IC50 = 250 µM).

Sigma-Aldrich

444200

MDL-12,330A, Hydrochloride

form

crystalline solid

form

crystalline solid

form

solid

form

solid

assay

≥98% (TLC)

assay

≥98% (NMR)

assay

>98% (TLC)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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SKUNUMER GTIN
681629-10MG04055977260144

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