481920-M
NAAG
NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system.
Synonim(y):
N-acetylo-Asp-Glu, N-acetyloaspargiloglutaminian; kwas spaglumowy
Wybierz wielkość
| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
Przewidywany termin wysyłki20 maja 2026zKuehne + Nagel Sp. z o.o. | 854,00 zł |
Informacje o tej pozycji
Quality Level
assay
≥98% (TLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL, methanol: 50 mg/mL
storage temp.
2-8°C
SMILES string
[Mg+2].N([C@@H](CCC(=O)[O-])C(=O)[O-])C(=O)[C@@H](NC(=O)C)CC(=O)[O-].[H+]
InChI
1S/C11H16N2O8.Mg/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16;/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21);/q;+2/p-2/t6-,7-;/m0./s1
InChI key
BQAXDBLSAIPBND-LEUCUCNGSA-L
General description
Preparation Note
Other Notes
Legal Information
Disclaimer
1 of 1
Ta pozycja | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥99% (HPLC) | assay ≥99% (HPLC) | assay - |
| form powder | form - | form powder | form - |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename Upstate® |
| Quality Level 100 | Quality Level 300 | Quality Level 300 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. - |
| solubility DMSO: 50 mg/mL, methanol: 50 mg/mL | solubility - | solubility - | solubility - |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Powiązane treści
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.