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Dokumenty

04-855

Sigma-Aldrich

Anti-GluR1 Antibody, clone C3T, rabbit monoclonal

culture supernatant, clone C3T, Upstate®

Synonim(y):

Anti-GluA1, Anti-GluR-1, Anti-GluR-A, Anti-GluR-K1, Anti-GluR1

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

forma przeciwciała

culture supernatant

rodzaj przeciwciała

primary antibodies

klon

C3T, monoclonal

reaktywność gatunkowa

human, chimpanzee, rat, mouse

producent / nazwa handlowa

Upstate®

metody

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

izotyp

IgG

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

dry ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... GRIA1(2890)

Opis ogólny

L glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors that have been divided into 3 groups. Group I includes GRM1 and these receptors have been shown to activate phospholipase C. GRM1 expression has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries.

Specyficzność

Predicted to cross-react with Chimpanzee based pm 100% sequence homology.
Recognizes GluR1, Mr 106 kDa.

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 858-868 (..TLPRNSGAGAS..) of human GluR1 (amino acids 840-850 of mature human GluR1)

Zastosowanie

Anti-GluR1 Antibody, clone C3T detects level of GluR1 & has been published & validated for use in IH, IP & WB.
Immunoprecipitation: 2 μL of a previous lot immunoprecipitated GluR1 from rat brain microsomal preparation.

Immunohistochemistry: A previous lot of this antibody has been shown to detect GluR1 in human, mouse and rat tissues.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Jakość

Routinely evaluated by Western blotting of rat brain microsomal preparation.

Western Blotting Analysis (WB): A 1:5,000-1:10,000 dilution of this lot detected GluR1 in rat brain microsomal preparation (Catalog # 12-144).

Opis wartości docelowych

106 kDa

Powiązanie

Replaces: 05-855

Postać fizyczna

Cultured supernantant in 0.05% sodium azide

Przechowywanie i stabilność

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Komentarz do analizy

Control
Routinely evaluated by immunoblot on rat brain microsomal preparation (12-144)

Informacje prawne

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 2


Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Gonadectomy differentially regulates steroid receptor coactivator-1 and synaptic proteins in the hippocampus of adult female and male C57BL/6 mice.
Chen Bian,Kongjiang Zhu,Li Yang,Sen Lin,Shurong Li,Bingyin Su,Jiqiang Zhang
Synapse null
A L Mammen et al.
The Journal of biological chemistry, 272(51), 32528-32533 (1998-01-24)
Modulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) receptors in the brain by protein phosphorylation may play a crucial role in the regulation of synaptic plasticity. Previous studies have demonstrated that calmodulin (CaM) kinase II can phosphorylate and modulate AMPA receptors. However, the
Membrane depolarization regulates AMPA receptor subunit expression in cerebellar granule cells in culture.
Incontro, S; Ramirez-Franco, J; Sanchez-Prieto, J; Torres, M
Biochimica et Biophysica Acta null
The striatal mosaic in primates: striosomes and matrix are differentially enriched in ionotropic glutamate receptor subunits.
Martin, L J, et al.
The Journal of Neuroscience, 13, 782-792 (1993)
Zhexing Wen et al.
Nature, 515(7527), 414-418 (2014-08-19)
Dysregulated neurodevelopment with altered structural and functional connectivity is believed to underlie many neuropsychiatric disorders, and 'a disease of synapses' is the major hypothesis for the biological basis of schizophrenia. Although this hypothesis has gained indirect support from human post-mortem

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