480030

NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control

A cell-permeable Antennapedia-NBD mutated fusion peptide analog of NEMO-Binding Domain Binding Peptide that serves as a negative control.

• Synonim(y): NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control, DRQIKIWFQNRRMKWKK-TALDASALQTE, NBD-Binding Peptide, Cell-Permeable, Negative Control
• Wzór empiryczny (zapis Hilla): C₁₅₄H₂₄₉N₄₇O₄₂S
• Masa cząsteczkowa: 3462.98
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: lyophilized solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: off-white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Opis

General description

A cell-permeable Antennapedia-NBD mutated (Trp⁷³⁹ and Trp⁷⁴¹ replaced with Ala) fusion peptide analog of NEMO-Binding Domain Binding Peptide (Cat. No. 480025) that serves as a negative control. Shown to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.

A cell-permeable, Antennapedia-NBD mutated (Trp⁷³⁹ → Ala and Trp⁷⁴¹ → Ala) fusion peptide analog of NEMO-Binding Domain Binding peptide (Cat. No. 480025) that serves as a negative control. Reported to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun or DNA binding of the transcription factor Oct-1.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Negative control defective in binding to NEMO

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

H₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH

Jimi, E., et al. 2004. Nat. Med., 10, 617.
May, M.J., et al. 2000. Science289, 1550.

This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations; however, sufficient material will stay in solution to permeate cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable