407272

Integrin αvβ3 Antagonist, P11

The Integrin αvβ3 Antagonist, P11 controls the biological activity of Integrin αvβ3.

• Synonim(y): Integrin αvβ3 Antagonist, P11, HSDVHK-NH2, HSDVHK
• Wzór empiryczny (zapis Hilla): C₃₀H₅₁N₁₂O₉₃ · 3C₂HF₃O₂
• Masa cząsteczkowa: 2409.82
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: water: 100 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Opis

General description

A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC₅₀ = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoracetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bang, J., et al. 2011. Mol Cell Proteomics10, M110.
Choi, Y., et al. 2010. Proteomics10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen.9, 687.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable