The stock solution of this product can be made in deionized water, at least up to a concentration of 10 mg/ml. For the application protocol, one may be interested in referring to the following citation: "Microvasc Res. 2020 Jul;130:104001. doi: 10.1016/j.mvr.2020.104001. Epub 2020 Mar 19. CASIN and AMD3100 enhance endothelial cell proliferation, tube formation, and sprouting. PMID: 32198058."
239820
AMD3100 octahydrochloride hydrate
≥98% (HPLC), solid, CXCR4 antagonist, Calbiochem
Synonim(y):
CXCR4 Antagonist I, AMD3100, 1,1ʹ-(1,4-Phenylene bis(methylene))- bis-1,4,8,11-tetraazacyclotetradecane, 8HCl, JM3100, 1,1ʹ-(1,4-Phenylenebis(methylene))-bis-1,4,8,11-tetraazacyclotetradecane, 8HCl, JM3100
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
5 mg | Przewidywany termin wysyłki07 września 2026zKuehne + Nagel Sp. z o.o. | 548,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C28H54N8 · 8HCl
Numer CAS:
Masa cząsteczkowa:
794.47
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
548,00 zł
Przewidywany termin wysyłki07 września 2026Szczegóły
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
CXCR4 Antagonist I, AMD3100, The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications.
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
off-white
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.N3(CCNCCCNCCNCCC3)Cc1ccc(cc1)CN2CCNCCCNCCNCCC2
InChI
1S/C28H54N8.8ClH/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H
InChI key
UEUPDYPUTTUXLJ-UHFFFAOYSA-N
General description
A symmetrical bicyclam compound that antagonizes CXCL12 (SDF1) binding to CXCR4 (IC50 = 108 and 245 nM using rat and human CXCR4, respectively) and inhibits SDF1-induced Ca2+ flux (by 100% at 100 ng/ml in SUP-T1 and THP-1 cultures) as well as CXCR4-, but not CCR5-, mediated HIV infection (IC50 ≤200 nM), while enhancing the binding of SDF1 to CXCR7 (by ~60% at 1 mM with CXCR7-expressing HEK293T cells) and SDF1-induced β-arrestin recruitment to CXCR7 (EC50 = 6.48 and 11.8 nM, in the presence and absence of 10 µM AMD3100, respectively). Administration AMD3100 via intravenous infusion is also reported to result in hematopoietic stem cell mobilization in humans, dogs, and mice in vivo. Exhibits no inhibitory effects against chemokine-induced signaling via CXCR1/2/3 or CCR1/2/3/4/5/6/7/8/9. Also available as a 50 mM solution in H2O (Cat. No. 239825).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Kalatskaya, I., et al. 2009. Mol. Pharmacol.77, 1240.
Pitchford, S.C., et al. 2009. Cell Stem Cell4, 62.
De Clercq, E. 2009. Biochem. Pharmacol. , 1655.
Thoma, G., et al. 2008. J. Med. Chem.51, 7915.
De Clercq, E. 2000. Mol. Pharmacol.57, 833.
Pitchford, S.C., et al. 2009. Cell Stem Cell4, 62.
De Clercq, E. 2009. Biochem. Pharmacol. , 1655.
Thoma, G., et al. 2008. J. Med. Chem.51, 7915.
De Clercq, E. 2000. Mol. Pharmacol.57, 833.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Ta pozycja | |||
|---|---|---|---|
| description The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications. | description InSolution, ≥98%, 50 mM aqueous solution, CXCR4 antagonist I | description A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. | description A cell-permeable DNA topoisomerase I inhibitor. |
| form solid | form liquid | form solid | form solid |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −70°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility water: 10 mg/mL | solubility - | solubility DMSO: 20 mg/mL, water: 20 mg/mL | solubility methanol: 40 mg/mL, DMSO: 10 mg/mL |
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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What type of solvent should be used with the CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem (#239820-15mg) for reconstitution? Is it DI water, PBS, medium, or something else?
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