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399250

N^G-Hydroxy-L-arginine, Monoacetate Salt

Name: N<sup>G</sup>-Hydroxy-L-arginine, Monoacetate Salt
Brand: MM
Price: 802 PLN
Availability: InStock

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

Synonim(y):

N^G-Hydroxy-L-arginine, Monoacetate Salt, NOHA, AcOH

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Gabaryty przesyłki	SKU	Dostępność	Cena netto
5 mg		Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.	802,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₆H₁₄N₄O₃ · xC₂H₄O₂

Numer CAS:

53598-01-9

Masa cząsteczkowa:

190.20 (free base basis)

UNSPSC Code:

12352209

NACRES:

NA.77

MDL number:

MFCD00216150

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

802,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

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Właściwości

Quality Segment

100

assay

≥98% (HPLC)

form

solid

potency

150 μM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[N+H3][C@@H](CCC\N=C(\NO)/N)C(=O)O.[O-]C(=O)C

InChI

1S/C6H14N4O3.C2H4O2/c7-4(5(11)12)2-1-3-9-6(8)10-13;1-2(3)4/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10);1H3,(H,3,4)/t4-;/m0./s1

InChI key

VYMCYRPQICLHKC-WCCKRBBISA-N

Opis

General description

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. A potent inhibitor of liver and macrophage arginase (K_i = 150 µM).

Cell-permeable. A key intermediate product in the biosynthesis of nitric oxide from arginine by constitutive nitric oxide synthase (cNOS). Formed by the NADPH-dependent hydroxylation of L-arginine. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450, providing an alternative biosynthetic route for the production of nitric oxide. A potent inhibitor of liver and macrophage arginase (K_i = 150 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
liver and macrophage arginase

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun.193, 963.
Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun.187, 880.
Stuehr, D.J., et al. 1991. J. Biol. Chem.266, 6259.
Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun.176, 528.
Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA88, 11172.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	399275	475886	311204
Sigma-Aldrich 399250 N^G-Hydroxy-L-arginine, Monoacetate Salt	Sigma-Aldrich 399275 N^ω-Hydroxy-nor-L-arginine, Diacetate Salt	Sigma-Aldrich 475886 N^G-Monomethyl-L-arginine, Monoacetate Salt	Sigma-Aldrich 311204 N^G,N^G′-Dimethyl-L-arginine, Dihydrochloride
assay ≥98% (HPLC)	assay ≥97% (TLC)	assay ≥99% (HPLC), ≥99% (TLC)	assay ≥97% (HPLC)
form solid	form solid	form solid	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. 10-30°C	storage temp. 2-8°C
solubility water: 1 mg/mL	solubility water: 50 mg/mL	solubility water: 50 mg/mL, methanol: soluble	solubility water: 50 mg/mL

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
399250-5MG	04055977212556

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