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399275

Nω-Hydroxy-nor-L-arginine diacetate Salt

≥97% (TLC), Arginase inhibitor, solid

Synonim(y):

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH3CO2H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH3CO2H

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Do Państwa/SKUDostępnośćCena netto
1 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

234,00 zł
5 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

596,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C5H12N4O3 · 2C2H4O2
Numer CAS:
189302-40-7
Masa cząsteczkowa:
296.28
MDL number:
MFCD01318777
UNSPSC Code:
12352209
NACRES:
NA.77
Assay:
≥97% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)

234,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

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Nazwa produktu

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, A potent, selective, competitive, and high affinity inhibitor of arginase.

Quality Segment

100

assay

≥97% (TLC)

form

solid

potency

2 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

off-white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

N(O)\C(=N\CC[C@H](N)C(=O)O)\N.OC(=O)C.OC(=O)C

InChI key

PQFYTZJPYBMTCT-QTNFYWBSSA-N

General description

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Biochem/physiol Actions

Primary Target
arginase from rat liver
Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)
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Ta pozycja
399250311204475886
Nω-Hydroxy-nor-L-arginine, Diacetate Salt A potent, selective, competitive, and high affinity inhibitor of arginase.

Sigma-Aldrich

399275

Nω-Hydroxy-nor-L-arginine, Diacetate Salt

NG-Hydroxy-L-arginine, Monoacetate Salt Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

Sigma-Aldrich

399250

NG-Hydroxy-L-arginine, Monoacetate Salt

NG,NG′-Dimethyl-L-arginine, Dihydrochloride Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.

Sigma-Aldrich

311204

NG,NG′-Dimethyl-L-arginine, Dihydrochloride

NG-Monometylo-L-arginina, sól monooctanowa Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of NOS.

Sigma-Aldrich

475886

NG-Monometylo-L-arginina, sól monooctanowa

assay

≥97% (TLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥99% (HPLC), ≥99% (TLC)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

10-30°C

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

Klasa składowania

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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