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344930

Furin Inhibitor I

≥90% (HPLC), solid, furin inhibitor, Calbiochem®

Synonim(y):

Furin Inhibitor I, Decanoyl-RVKR-CMK

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Gabaryty przesyłkiSKUDostępnośćCena netto
1 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

1120,00 zł
150 mg

Przewidywany termin wysyłki08 lipca 2026zKuehne + Nagel Sp. z o.o.

82 060,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C34H66ClN11O5
Masa cząsteczkowa:
744.41
UNSPSC Code:
12352200
NACRES:
NA.28
Assay:
≥90% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated

1120,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

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Nazwa produktu

Furin Inhibitor I, Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

Quality Level

100

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

off-white

solubility

methanol: 1 mg/mL, DMSO: soluble

shipped in

ambient

storage temp.

−20°C

General description

A peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
A peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Cell permeable: yes
Primary Target
viral glycoproteins

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Decanoyl-Arg-Val-Lys-Arg-CMK
Sugrue, R.J., et al. 2001. J. Gen. Virol.82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem.276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol.26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)
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Ta pozycja
218744539160219421
Furin Inhibitor I Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

Sigma-Aldrich

344930

Furin Inhibitor I

Caspase-2 Inhibitor I The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

218744

Caspase-2 Inhibitor I

Proteasome Inhibitor I The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

539160

Proteasome Inhibitor I

Cathepsin L Inhibitor I The Cathepsin L Inhibitor I, also referenced under CAS 108005-94-3, controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

219421

Cathepsin L Inhibitor I

form

solid

form

lyophilized

form

solid

form

solid

assay

≥90% (HPLC)

assay

≥95% (HPLC), ≥95% (TLC)

assay

≥90% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

methanol: 1 mg/mL, DMSO: soluble

solubility

DMSO: 5 mg/mL

solubility

DMSO: 30 mg/mL, ethanol: 30 mg/mL, methanol: soluble

solubility

DMSO: 20 mM

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Odwiedź Bibliotekę dokumentów

Montalbano Mauro et al.
International journal of molecular sciences, 24(13) (2023-07-14)
Glypican-3 (GPC-3) is a heparin sulfate proteoglycan located extracellularly and anchored to the cell membrane of transformed hepatocytes. GPC-3 is not expressed in normal or cirrhotic liver tissue but is overexpressed in hepatocellular carcinoma (HCC). Because of this, GPC-3 is
Zhujun Ao et al.
iScience, 25(8), 104759-104759 (2022-07-21)
The Delta variant had spread globally in 2021 and caused more serious disease than the original virus and Omicron variant. In this study, we investigated several virological features of Delta spike protein (SPDelta), including protein maturation, its impact on viral
Fangyuan Chen et al.
Molecular systems biology, 17(8), e10239-e10239 (2021-08-03)
Understanding the mechanism of SARS-CoV-2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharmacology approach, we identified a set of repurposable and investigational drugs as potential therapeutics against COVID-19. These were deduced from the gene expression
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SKUNUMER GTIN
344930-1MG04055977194371
344930-150MG04055977194388

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