219421

Cathepsin L Inhibitor I

The Cathepsin L Inhibitor I, also referenced under CAS 108005-94-3, controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonim(y): Cathepsin L Inhibitor I, Z-FF-FMK
• Wzór empiryczny (zapis Hilla): C₂₇H₂₇FN₂O₄
• Numer CAS: 108005-94-3
• Masa cząsteczkowa: 462.51
• MDL number: MFCD24369030
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: solid
• Storage condition: OK to freeze, desiccated

Właściwości

• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white
• solubility: DMSO: 20 mM
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: FCC(=O)C(NC(=O)C(NC(=O)OCc3ccccc3)Cc2ccccc2)Cc1ccccc1
• InChI: 1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(H,30,33)
• InChI key: CAILNONEKASNSH-UHFFFAOYSA-N

Opis

General description

A potent, cell-permeable and irreversible inhibitor of cathepsin L.

A potent, cell-permeable, and irreversible inhibitor of Cathepsin L (Cat. No. 219402 ).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cathepsin L

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Analysis Note

single spot by TLC

Other Notes

Ravanko, K., et al. 2004. Cancer Res.64, 8831.
Esser, R.E., et al. 1994. Arthritis Rheum. 37, 236.
Shaw, E., et al. 1993. FEBS Lett.334, 340.

Z-Phe-Phe-CH₂F

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable