344847

Fumitremorgin C

from Aspergillus. fumigatus, ≥95% (HPLC), lyophilized, BCRP/ABCG2 inhibitor, Calbiochem^®

• Synonim(y): Fumitremorgin C, Aspergillus. fumigatus, NSC719655, FTC
• Wzór empiryczny (zapis Hilla): C₂₂H₂₅N₃O₃
• Numer CAS: 118974-02-0
• Masa cząsteczkowa: 379.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD08702652
• Assay: ≥95% (HPLC)
• Form: lyophilized
• Storage condition: OK to freeze, protect from light

Właściwości

• Nazwa produktu: Fumitremorgin C, Aspergillus. fumigatus, A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• solubility: DMSO: 10 mg/mL, ethanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: N21[C@@H](Cc4c5c([nH]c4[C@@H]2C=C(C)C)cc(cc5)OC)C(=O)N3[C@@H](CCC3)C1=O
• InChI: 1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1
• InChI key: DBEYVIGIPJSTOR-FHWLQOOXSA-N

Opis

General description

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417.
Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111.
Rabindran, S.K., et al. 2000. Cancer Res.60, 47.
Rabindran, S.K., et al. 1998. Cancer Res.58, 5850.
Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable