344845

Fumagillin, Aspergillus fumigatus

Antiprotozoal agent and angiogenesis inhibitor.

• Synonim(y): Fumagillin, Aspergillus fumigatus
• Wzór empiryczny (zapis Hilla): C₂₆H₃₄O₇
• Numer CAS: 23110-15-8
• Masa cząsteczkowa: 458.54
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD03990453
• Assay: ≥90% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Level: 100
• description: Merck USA index - 14, 4286
• assay: ≥90% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white to off-white
• solubility: methanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Opis

General description

An inhibitor of angiogenesis. Has selective cytostatic effects against ras transformed cells (IC₅₀ = 10 pM). Antiprotozoal agent active against sporozoan parasites in bees and myxozoan parasites in fish.

Antiprotozoal agent and angiogenesis inhibitor. Acts as an inhibitor of methionine amino-peptidase 2.

Biochem/physiol Actions

Primary Target
Methionine amino-peptidase 2

Product does not compete with ATP.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Zhang, P., et al. 2002. J. Biomed. Sci.9, 34.
Stepien, H., et al. 1996. J. Endocrinol.150, 99.
Abrams, J.S., et al. 1994. Cancer74, 1164.
Jenkins, D.C., et al. 1993. Br. J. Cancer68, 856.
Le Querrec, A., et al. 1993. Baillieres Clin. Hematol.6, 711.
Molnar, K. 1993. Acta Vet. Hung. 41, 51.
Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
Brackett, J.M., et al. 1988. J. Agric. Food Chem.36, 762.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable