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232120

cis-Diammineplatinum(II) dichloride

≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem

Synonim(y):

Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum

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Gabaryty przesyłkiSKUDostępnośćCena netto
50 mg
Sprawdź dostępność w koszyku
742,00 zł

Informacje o tej pozycji

Wzór liniowy:
Pt(NH3)2Cl2
Numer CAS:
15663-27-1
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00011623
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze

742,00 zł

Sprawdź dostępność w koszyku
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Nazwa produktu

Cisplatin, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

Quality Level

100

description

Merck USA index - 14, 2317

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

yellow

solubility

PBS with 140 mM NaCl: 1 mg/mL, water with 154 mM NaCl: 1 mg/mL, DMSO: 10 mg/mL

shipped in

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Ta pozycja
PHR16241134357C2210000
Cisplatin Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

Sigma-Aldrich

232120

Cisplatin

Cisplatin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1624

Cisplatin

Cisplatin United States Pharmacopeia (USP) Reference Standard

USP

1134357

Cisplatin

Cisplatin European Pharmacopoeia (EP) Reference Standard

C2210000

Cisplatin

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

USP

manufacturer/tradename

EDQM

form

solid

form

-

form

-

form

-

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

storage condition

OK to freeze

storage condition

-

storage condition

-

storage condition

-

solubility

PBS with 140 mM NaCl: 1 mg/mL, DMSO: 10 mg/mL, water with 154 mM NaCl: 1 mg/mL

solubility

-

solubility

-

solubility

-

General description

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Induces apoptosis in cancer cells
Product does not compete with ATP.
Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)
Ta strona może zawierać tekst przetłumaczony maszynowo.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

target_organs

Respiratory system

Klasa składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Jinan Li et al.
Frontiers in molecular neuroscience, 15, 835448-835448 (2022-03-01)
Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin. In zebrafish, the functional mechanotransduction channel is
Laura Torresano et al.
Oncogenesis, 11(1), 24-24 (2022-05-10)
Lung cancer is the leading cause of cancer-related death worldwide despite the success of therapies targeting oncogenic drivers and immune-checkpoint inhibitors. Although metabolic enzymes offer additional targets for therapy, the precise metabolic proteome of lung adenocarcinomas is unknown, hampering its
Shruthi Sriramkumar et al.
Journal of translational medicine, 20(1), 246-246 (2022-06-02)
Platinum based agents-cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant disease that is uniformly fatal. Platinum treatment enriches for chemoresistant aldehyde
Adib Behrouzi et al.
International journal of molecular sciences, 23(3) (2022-02-16)
Cisplatin can induce peripheral neuropathy, which is a common complication of anti-cancer treatment and negatively impacts cancer survivors during and after completion of treatment; therefore, the mechanisms by which cisplatin alters sensory neuronal function to elicit neuropathy are the subject
Jiaqi Liu et al.
eLife, 10 (2021-12-18)
Gliomas are highly malignant brain tumors with poor prognosis and short survival. NAD+ has been shown to impact multiple processes that are dysregulated in cancer; however, anti-cancer therapies targeting NAD+ synthesis have had limited success due to insufficient mechanistic understanding.
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Numer pozycji handlu globalnego

SKUNUMER GTIN
232120-50MG04055977217605

Questions

  1. The SDS seems to contain the wrong information. It does not match the information on the vial and on the website.

    1 answer

    1. The Safety Data Sheet document provided on the product detail page is the correct document. Please access document below: https://www.sigmaaldrich.com/US/en/sds/mm/232120

      For further concerns, we kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquires" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

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