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218860

Casein Kinase II Inhibitor VIII

Name: Casein Kinase II Inhibitor VIII
Brand: MM

The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonim(y):

Casein Kinase II Inhibitor VIII, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII, 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₈H₁₄N₂O₄S

Numer CAS:

1361229-76-6

Masa cząsteczkowa:

354.38

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD28127268

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Właściwości

Quality Segment

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

O=C(C1=CC=C(OC)C=C1)NC2=NC=C(C3=CC=C(C(O)=O)C=C3)S2

InChI

1S/C18H14N2O4S/c1-24-14-8-6-12(7-9-14)16(21)20-18-19-10-15(25-18)11-2-4-13(5-3-11)17(22)23/h2-10H,1H3,(H,22,23)(H,19,20,21)

InChI key

UPIVZLFKYMNZDG-UHFFFAOYSA-N

Opis

General description

A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC₅₀ = 32 and 46 nM against CK2α and CK2α′, respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC₅₀ = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).

Biochem/physiol Actions

Secondary Target
DYRK1B, Flt-3

Target IC₅₀: 32 and 46 nM for CK2&alpha

Cell permeable: yes

Primary Target
CK2

Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Hou, Z., et al. 2012. J. Med. Chem.55, 2899.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	218697	676481	218710
Sigma-Aldrich 218860 Casein Kinase II Inhibitor VIII	Sigma-Aldrich 218697 Casein Kinase II Inhibitor I	Sigma-Aldrich 676481 VEGFR Tyrosine Kinase Inhibitor II	Sigma-Aldrich 218710 Casein Kinase II Inhibitor III, TBCA
form solid	form solid	form solid	form solid
assay ≥99% (HPLC)	assay ≥99% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 50 mg/mL	solubility DMSO: 10 mg/mL	solubility DMSO: 5 mg/mL, methanol: soluble	solubility DMSO: 10 mg/mL (Use only fresh DMSO.), ethanol: 5 mg/mL

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c