218710

Casein Kinase II Inhibitor III, TBCA

The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonim(y): Casein Kinase II Inhibitor III, TBCA, (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
• Wzór empiryczny (zapis Hilla): C₉H₄Br₄O₂
• Numer CAS: 934358-00-6
• Masa cząsteczkowa: 463.74
• MDL number: MFCD20921901
• UNSPSC Code: 12352200
• NACRES: NA.54
• Assay: ≥95% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• potency: 110 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 10 mg/mL (Use only fresh DMSO.), ethanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Brc1c(c(cc(c1Br)\C=C\C(=O)O)Br)Br
• InChI: 1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+
• InChI key: SVJQCVOKYJWUBC-OWOJBTEDSA-N

Opis

General description

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target K_i: 77 nM against Casein Kinase II

Packaging

Packaged under inert gas

Other Notes

Pagano, M.A., et al. 2006. Chembiochem8, 129

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2