165304
Kwas D-(-)-2-amino-5-fosfonopentanowy
≥97% (HPLC), solid, NMDA receptor antagonist, Calbiochem®
Synonim(y):
D-AP5, antagonista NMDA II, APV, D-APV, 2-APV, D-2-amino-5-fosfonowalerian
Wybierz wielkość
| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 693,00 zł |
Informacje o tej pozycji
693,00 zł
Nazwa produktu
Kwas D-(-)-2-amino-5-fosfonopentanowy, Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used as a competitive NMDA receptor antagonist.
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
dilute aqueous base: 1 mg/mL, water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[P](=O)([O-])([O-])CCC[C@@H]([N+H3])C(=O)[O-]
InChI
1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/p-2/t4-/m1/s1
InChI key
VOROEQBFPPIACJ-SCSAIBSYSA-L
General description
Biochem/physiol Actions
NMDA receptor antagonist
Preparation Note
Other Notes
Schulte, M.K., et al. 1994. Brain Res. 649, 203.
Davis, S., et al. 1992. J. Neurosci. 12, 21.
Legal Information
Disclaimer
1 of 1
Ta pozycja | |||
|---|---|---|---|
| assay ≥97% (HPLC) | assay >95% (TLC) | assay ≥97% (titration) | assay ≥97% (HPLC) |
| form solid | form solid | form crystalline solid | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| storage temp. 2-8°C | storage temp. 10-30°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility dilute aqueous base: 1 mg/mL, water: 1 mg/mL | solubility water: 1 mg/mL | solubility DMSO: 20 mg/mL, 95% ethanol: 25 mg/mL | solubility DMSO: 50 mg/mL |
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Powiązane treści
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 165304-5MG | 04055977207668 |