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Merck

165304

Kwas D-(-)-2-amino-5-fosfonopentanowy

≥97% (HPLC), solid, NMDA receptor antagonist, Calbiochem®

Synonim(y):

D-AP5, antagonista NMDA II, APV, D-APV, 2-APV, D-2-amino-5-fosfonowalerian

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Wybierz wielkość

5 MG

693,00 zł

693,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C5H12NO5P
Numer CAS:
79055-68-8
Masa cząsteczkowa:
197.13
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
MFCD00078839
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

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Nazwa produktu

Kwas D-(-)-2-amino-5-fosfonopentanowy, Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used as a competitive NMDA receptor antagonist.

color

white

SMILES string

[P](=O)([O-])([O-])CCC[C@@H]([N+H3])C(=O)[O-]

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/p-2/t4-/m1/s1

InChI key

VOROEQBFPPIACJ-SCSAIBSYSA-L

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

solubility

dilute aqueous base: 1 mg/mL, water: 1 mg/mL

shipped in

ambient

Quality Level

100

storage temp.

2-8°C

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Ta pozycja
454575100065138001
D-(–)-2-Amino-5-phosphonopentanoic Acid Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used as a competitive NMDA receptor antagonist.

Sigma-Aldrich

165304

D-(–)-2-Amino-5-phosphonopentanoic Acid

N-Methyl-D-aspartic Acid, Hydrate Excitatory amino acid neurotransmitter.

Sigma-Aldrich

454575

N-Methyl-D-aspartic Acid, Hydrate

2-APB A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.

Sigma-Aldrich

100065

2-APB

D-Amino Acid Oxidase Inhibitor II, CBIO The D-Amino Acid Oxidase Inhibitor II, CBIO, also referenced under CAS 61977-29-5, controls the biological activity of D-Amino Acid Oxidase.

Sigma-Aldrich

138001

D-Amino Acid Oxidase Inhibitor II, CBIO

form

solid

form

solid

form

crystalline solid

form

powder

assay

≥97% (HPLC)

assay

>95% (TLC)

assay

≥97% (titration)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

10-30°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

OK to freeze

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, protect from light

General description

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used as a competitive NMDA receptor antagonist. Also inhibits the capsaicin-induced release of substance P from spinal cord.

Biochem/physiol Actions

Cell permeable: no
Primary Target
NMDA receptor antagonist
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Malcangio, M., et al. 1998. Br. J. Pharmacol. 125, 1625.
Schulte, M.K., et al. 1994. Brain Res. 649, 203.
Davis, S., et al. 1992. J. Neurosci. 12, 21.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)
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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Jing Zhou et al.
eLife, 10 (2021-03-05)
Callosal projections from primary somatosensory cortex (S1) are key for processing somatosensory inputs and integrating sensory-motor information. How the callosal innervation pattern in S1 is formed during early postnatal development is not clear. We found that the normal termination pattern
Yu-Hong Zhang et al.
Cell stem cell, 28(8), 1483-1499 (2021-04-23)
The hypothalamus contains an astounding heterogeneity of neurons that regulate endocrine, autonomic, and behavioral functions. However, its molecular developmental trajectory and origin of neuronal diversity remain unclear. Here, we profile the transcriptome of 43,261 cells derived from Rax+ hypothalamic neuroepithelium
Hitomi Abe et al.
iScience, 25(3), 103927-103927 (2022-03-15)
Understanding the molecular mechanisms of gene regulation is pivotal for understanding how cells establish and modify their identities and functions. Multiple transcription factors (TFs) coordinate to alter gene expression in cells; however, a method to quantitatively analyze the activity of

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Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

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