These products are for research use only and have not been evaluated for in vivo applications. To assess potential differences between this product and M3262, it is recommended to consult the Certificates of Analysis: https://www.sigmaaldrich.com/product/mm/454575#product-documentation and https://www.sigmaaldrich.com/product/sigma/m3262#product-documentation
454575
N-Methyl-D-aspartic Acid hydrate
>95% (TLC), solid, excitatory amino acid neurotransmitter, Calbiochem®
Synonim(y):
N-Methyl-D-aspartic Acid, Hydrate, NMDA
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 100 mg | Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o. | 742,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C5H9NO4 · xH2O
Numer CAS:
Masa cząsteczkowa:
147.13 (anhydrous basis)
UNSPSC Code:
12352209
NACRES:
NA.77
MDL number:
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
N-Methyl-D-aspartic Acid, Hydrate, Excitatory amino acid neurotransmitter.
Quality Level
description
Merck USA index - 14, 6662
assay
>95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
N([C@H](CC(=O)O)C(=O)[O-])C
InChI
1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
InChI key
HOKKHZGPKSLGJE-GSVOUGTGSA-M
General description
An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca2+ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.
Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca2+ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Glutamate receptor that regulates Ca2+ channels
Glutamate receptor that regulates Ca2+ channels
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.
Other Notes
Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Ta pozycja | |||
|---|---|---|---|
| form solid | form solid | form solid | form solid |
| assay >95% (TLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥99% (TLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
| storage temp. 10-30°C | storage temp. 2-8°C | storage temp. 10-30°C | storage temp. 10-30°C |
| storage condition OK to freeze | storage condition OK to freeze, desiccated (hygroscopic), protect from light | storage condition OK to freeze | storage condition do not freeze |
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certyfikaty analizy (CoA)
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Powiązane treści
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
Xinzheng Guo et al.
STAR protocols, 2(4), 100932-100932 (2021-11-23)
The degeneration of retinal ganglion cells (RGCs) leads to irreversible vision loss in a variety of pathological states. Here, we describe a protocol to evaluate the role of a gene in protecting mouse RGCs when they sustain injuries from excitotoxicity
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 454575-100MG | 04055977204148 |
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What's the difference between CAS Number: 6384-92-5 and CAS Number:454575? (They are both NMDA). Which are applicable to be used in a NMDA lesion surgery?
1 answer-
Helpful?
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