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14-520-M

Kinaza kazeinowa 1δ (aa 1-294) Białko, aktywne, 10 µg

Name: Kinaza kazeinowa 1δ (aa 1-294) Białko, aktywne, 10 µg
Brand: MM
Price: 2400 PLN
Availability: InStock

Active, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.

Synonim(y):

Białko kinazy

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Gabaryty przesyłki	SKU	Dostępność	Cena netto
10 μg		Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.	2400,00 zł
250 μg		Przewidywany termin wysyłki20 maja 2026zKuehne + Nagel Sp. z o.o.	15 770,00 zł

Informacje o tej pozycji

UNSPSC Code:

12352202

NACRES:

NA.32

eCl@ss:

32160405

Biological source:

human

Recombinant:

expressed in E. coli

2400,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

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Właściwości

biological source

human

Quality Level

100

recombinant

expressed in E. coli

mol wt

M_w 61 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

Opis

General description

Research area: Cell signaling

Research Category: Metabolism Research

Subcategory: Obesity

Protein Target: CK1γδ

Target Sub-Family: CK1

Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1.[1] The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).

Application

Research Category
Metabolism

Research Sub Category
Obesity

Metabolic Disorders

Biochem/physiol Actions

Casein Kinase 1δ (CK1δ) is implicated in multiple cellular processes, including membrane trafficking, cytokinesis, circadian rhythm, and tumorigenesis. It interacts with critical molecules within cancer-related signaling pathways, such as Wnt/β-catenin, PI3K/AKT, and Hedgehog. Therefore, mutations or overexpression of the CK1δ coding gene can potentially contribute to the onset and progression of cancer.[1]

Packaging

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.

Physical form

Glutathione-agarose

Preparation Note

6 months at -20°C

Analysis Note

routinely evaluated by phosphorylation of KRRRALS(p)VASLPGL

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Ta pozycja	14-712-M	14-689-M	14-197-M
Sigma-Aldrich 14-520-M Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg	Sigma-Aldrich 14-712-M Casein Kinase 1γ2 Protein, active, 10 µg	Sigma-Aldrich 14-689-M Casein Kinase 2α2 Protein, active, 10 µg	Sigma-Aldrich 14-197-M Casein Kinase 2 Protein, active, 10 µg
Gene Information human ... CSNK1D(1453)	Gene Information -	Gene Information -	Gene Information -
technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)
biological source human	biological source human	biological source human	biological source human
recombinant expressed in E. coli	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in Sf21 cells	recombinant expressed in Sf21 cells
UniProt accession no. P48730	UniProt accession no. P78368	UniProt accession no. P19784	UniProt accession no. P68400
mol wt M_w 61 kDa	mol wt M_w 49.7 kDa	mol wt M_w 45.8 kDa	mol wt α-subunit M_w 49 kDa (heterotetramer; α₂β₂), β subunit M_w 53 kDa (heterotetramer; α₂β₂)

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Klasa składowania

10 - Combustible liquids

wgk

WGK 2

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Odwiedź Bibliotekę dokumentów

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)

Xu P, et al.

Gene: X, 2019-2019 (2019)

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)

Xu P, et al.

A Manual for Genetic Engineering: Advanced Bacterial Genetics, 715 (2019)

Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase.

Francesca Vena et al.

Molecular cancer therapeutics, 19(8), 1623-1635 (2020-05-21)

Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial, there is a strong association between activating

Numer pozycji handlu globalnego

SKU	NUMER GTIN
14-520	04053252401565
14-520M	04053252321559

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