This product is tested in a kinase assay using cdk2/cyclin A, active (14-448), to phosphorylate histone H1. The Certificate of Analysis contains the kinase assay procedure.
14-155
Białko histonu H1, 20 mg
Purified bovine Histone H1 protein for use as a substrate in histone modification assays (HAT, HDAC, DNMT) and chromatin assembly studies.
Synonim(y):
Łącznik Histone H1
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 20 mg | Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o. | 2080,00 zł |
Informacje o tej pozycji
UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
bovine
Mol wt:
Mw 32 kDa
2080,00 zł
Dostępne do wysyłki DZISIAJSzczegóły
Pomoc techniczna
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Pozwól nam pomócbiological source
bovine
Quality Level
mol wt
Mw 32 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
shipped in
dry ice
General description
H1 and related linker histones are important both for maintenance of higher-order chromatin structure and for the regulation of gene expression. Nucleosomal stabilization is provided through the binding of histone H1 to the nucleosomal dyad and the linker DNA entering and exiting the core particle. Additional experimental evidence illustrates the influence of histone H1 on chromatin arrangement and compaction. The family of histone H1 proteins contains five somatic variants (H1.1, H1.2, H1.3, H1.4 and H1.5) which are expressed in nearly all cell types.
Product Source: Lysine rich fraction from calf thymus
Physical form
Sterilized through a 0.2 micron membrane filter
Preparation Note
1 year at -20°C
Analysis Note
Routinely evaluated by Kinase assay using cdk2/cyclin A, active (14-448) to phosphorylate Histone H1.
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Ta pozycja | |||
|---|---|---|---|
| technique(s) activity assay: suitable (kinase) | technique(s) immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable | technique(s) - | technique(s) dot blot: suitable, western blot: suitable |
| biological source bovine | biological source mouse | biological source human | biological source rabbit |
| mol wt Mw 32 kDa | mol wt - | mol wt - | mol wt - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| shipped in dry ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
| NCBI accession no. | NCBI accession no. | NCBI accession no. - | NCBI accession no. |
Klasa składowania
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
B Ouyang et al.
The Journal of biological chemistry, 272(45), 28646-28651 (1997-11-14)
Human prk encodes a novel protein serine/threonine kinase capable of strongly phosphorylating casein but not histone H1 in vitro. prk expression is tightly regulated at various levels during different stages of the cell cycle in lung fibroblasts. The Prk kinase
Hyo Kyun Chung et al.
The Journal of biological chemistry, 278(30), 28079-28088 (2003-04-30)
The Gadd45 family of proteins includes Gadd45alpha, MyD118/Gadd45beta, and CR6/OIG37/Gadd45gamma. These proteins play important roles in maintaining genomic stability and in regulating the cell cycle. This study reports the cloning of a novel protein called CR6-interacting factor 1 (CRIF1) which
J Pan et al.
Oncogene, 29(47), 6245-6256 (2010-08-31)
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2-knockout (Jdp2KO) mice by targeting exon-1
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 14-155 | 04053252362125 |
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Hi can this be used for enzymatic assays?
1 answer-
Helpful?
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Sowohl die NCBI- als auch die Uni-Prot Nummer führen zu einer humanen Datenkarte, anstatt zu einer bovinen. Warum?
1 answer-
Thank you for notifying us about the mismatch. Please find the relevant links here:
https://www.ncbi.nlm.nih.gov/gene/617854
https://www.uniprot.org/uniprotkb/G3MWV5/entryHelpful?
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