124005

Inhibitor Akt

≥98% (NMR), Akt (PKB) and PI 3-K inhibitor, solid

• Synonim(y): 1L6-hydroksymetylo-chiro-inozytol-2-(R)-2-O-metylo-3-O-oktadecylo- sn-glicerokarbonat, 1L6-hydroksymetylo-chiro-inozytol-2-(R)-2-O-metylo-3-O-oktadecylo-sn-glicerowęglan
• Wzór empiryczny (zapis Hilla): C₃₀H₅₈O₁₀
• Masa cząsteczkowa: 578.78
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (NMR)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Właściwości

• Nazwa produktu: Inhibitor Akt, The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• Quality Segment: 100
• assay: ≥98% (NMR)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white to off-white
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Opis

General description

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1 - 10 µM range.

Biochem/physiol Actions

Product competes with ATP.

Reversible: yes

Target IC₅₀: 5.0 µM for Akt (PKB)

Cell permeable: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.

Use anhydrous DMSO for reconstitution.

Other Notes

Hu, Y., et al. 2000 J. Med. Chem.43, 3045.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable