123041

AICA-rybozyd, 5′-fosforan

A 5′-phosphorylated analog of membrane permeable AICA-Riboside that mimics AMP and acts as an activator of AMPK (AMP-activated protein kinase).

• Synonim(y): AICA-Ribotide, monofosforan AICAr, ZMP, aktywator sygnalizacji AMPK IV
• Wzór empiryczny (zapis Hilla): C₉H₁₅N₄O₈P
• Numer CAS: 3031-94-5
• Masa cząsteczkowa: 338.21
• MDL number: MFCD00057264
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Właściwości

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white to light pink
• solubility: water: 1 mg/mL, DMSO: 30 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [P](=O)(OCC1OC(C(C1O)O)[n]2cnc(c2N)C(=O)N)(O)O
• InChI: 1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)
• InChI key: NOTGFIUVDGNKRI-UHFFFAOYSA-N

Opis

General description

A 5′-phosphorylated analog of membrane permeable AICA-Riboside (Cat. No. 123040) that mimics AMP and acts as an activator of AMPK (AMP-activated protein kinase).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activator of AMPK (AMP-activated protein kinase)

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Only water soluble following extensive heating.

Other Notes

Fryer, L.G.D., et al. 2002. Biochem. J.363, 167.
Henin, N., et al. 1996. Biochim. Biophys. Acta1290, 197.
Corton, J.M., et al. 1995. Eur. J. Biochem.229, 558.
Sullivan, J.E., et al. 1994. Biochem. Biophys. Res. Commun.200, 1551.
Sabina, R.L., et al. 1985. J. Biol. Chem.260, 6107.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable