1.04166

Urea

granulated, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP, ACS

• Synonim(y): Carbamide, Carbonyldiamide
• Wzór liniowy: NH₂CONH₂
• Numer CAS: 57-13-6
• Masa cząsteczkowa: 60.06
• UNSPSC Code: 12352111
• Beilstein/REAXYS Number: 635724
• MDL number: MFCD00008022

Właściwości

• grade: ACS reagent
• Quality Level: 500
• agency: BP, ChP, JP, Ph. Eur., USP
• product line: EMPROVE^® EXPERT
• form: granular
• pH: 9
• mp: 132-135 °C (lit.)
• density: 1.335 g/mL at 25 °C (lit.)
• application(s): liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• shipped in: ambient
• SMILES string: NC(N)=O
• InChI: 1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
• InChI key: XSQUKJJJFZCRTK-UHFFFAOYSA-N

Opis

General description

Standard bulk materials often show a tendency for caking, clumping and dust formation which results in laborious weighing processes and manual de-caking processes with a negative impact on manufacturing efficiency. Due to its granulated form, granulated urea is free-flowing and easy to handle. Its greatly reduced caking behavior facilitates processability, speeds up manufacturing processes and increases operator safety.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Urea is typically used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. It is useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. Urea may be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.
Due to its low microbial and endotoxin limits, Urea granulated Emprove^® Expert is especially suitable for high-risk applications.

Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• flash_point_f: Not applicable
• flash_point_c: Not applicable
• Klasa składowania: 13 - Non Combustible Solids