1.00160

Boric acid

crystalline, EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, NF, ChP

• Synonim(y): Orthoboric acid, Trihydroxidoboron
• Wzór liniowy: H₃BO₃
• Numer CAS: 10043-35-3
• Masa cząsteczkowa: 61.83
• UNSPSC Code: 12352301
• EC Index Number: 233-139-2
• MDL number: MFCD00011337

Właściwości

• Quality Segment: 500
• agency: BP, ChP, JP, NF, Ph. Eur.
• vapor pressure: 2.6 mmHg ( 20 °C)
• product line: EMPROVE^® ESSENTIAL
• assay: 99.5-100.5% dry basis (alkalimetric)
• form: crystalline, solid
• technique(s): API processing | cocrystal formation: suitable, API processing | salt formation: suitable
• pH: 3.8-4.8 (20 °C, 33 g/L in H₂O)
• mp: 160 °C (dec.) (lit.)
• solubility: 49.2 g/L
• density: 1.489 g/cm³ at 23 °C
• anion traces: sulfate (SO₄^2-): ≤0.04%
• cation traces: As: ≤0.0001%, heavy metals (as Pb): ≤0.0015%
• application(s): liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation
• storage temp.: 2-30°C
• SMILES string: OB(O)O
• InChI: 1S/BH3O3/c2-1(3)4/h2-4H
• InChI key: KGBXLFKZBHKPEV-UHFFFAOYSA-N

Opis

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Boric acid has antimicrobial characteristics and is therefore typically used as preservative in pharmaceutical formulations and cosmetics. It is also used as buffering agent and pH adjuster.

Preparation Note

Must be subjected to further processing during the preparation of injectable dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08
• signalword: Danger
• hcodes: H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects