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1270377

USP

Fexofenadine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonim(y):

Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine carboxylate hydrochloride

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About This Item

Wzór empiryczny (zapis Hilla):
C32H39NO4 · HCl
Numer CAS:
153439-40-8
Masa cząsteczkowa:
538.12
Numer MDL:
MFCD00865710
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329749845
NACRES:
NA.24

klasa czystości

pharmaceutical primary standard

rodzina API

fexofenadine

producent / nazwa handlowa

USP

Zastosowanie

pharmaceutical (small molecule)

format

neat

ciąg SMILES

Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

Klucz InChI

RRJFVPUCXDGFJB-UHFFFAOYSA-N

informacje o genach

human ... HRH1(3269)

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Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Fexofenadine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Extended-Release Tablets
  • Fexofenadine Hydrochloride Capsules
  • Fexofenadine Hydrochloride Tablets

Działania biochem./fizjol.

Fexofenadine is a non-sedating H1 histamine receptor antagonist.

Komentarz do analizy

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Inne uwagi

Sales restrictions may apply.
This page may contain text that has been machine translated.

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Fexofenadine impurity A,, European Pharmacopoeia (EP) Reference Standard

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Fexofenadine impurity B, European Pharmacopoeia (EP) Reference Standard

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Fexofenadine impurity C, European Pharmacopoeia (EP) Reference Standard

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Fexofenadine hydrochloride, British Pharmacopoeia (BP) Reference Standard

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PHR9043

α,α-Diphenyl-4-piperidinemethanol, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9103

Fexofenadine methyl ester, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2454

Fexofenadine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Erik Sjögren et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 214-223 (2013-10-01)
The pharmacokinetics (PK) of fexofenadine (FEX) in pigs were investigated with the focus on exploring the interplay between hepatic transport and metabolism when administered intravenously (iv) alone or with verapamil. The in vivo pig model enabled simultaneous sampling from plasma
Takayo Haruna et al.
Pharmacology, 95(1-2), 95-103 (2015-02-28)
We have previously reported that S-777469 [1-([6-ethyl-1-(4-fluorobenzyl)-5-methyl-2-oxo-1,2-dihydropyridine-3-carbonyl]amino)-cyclohexanecarboxylic acid], a novel cannabinoid type 2 receptor (CB2) agonist, significantly suppressed compound 48/80-induced scratching behavior in mice in a dose-dependent manner when it was administered orally. Here, we demonstrated that the inhibitory effects
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Yoshiyuki Shirasaka et al.
Pharmaceutical research, 31(8), 2035-2043 (2014-02-20)
OATP2B1-mediated grapefruit juice (GFJ)-drug interactions are substrate-dependent; for example, GFJ ingestion significantly reduces bioavailability of fexofenadine, but not pravastatin. In the present study, we aimed to establish whether this observation can be explained by the presence of multiple binding sites
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