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Z4250

Zymosan A from Saccharomyces cerevisiae

for inducing inflamatory response

Synonim(y):

Yeast Cell Wall

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Do Państwa/SKUDostępnośćCena netto
250 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
347,00 zł
1 g
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
1230,00 zł
5 g
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
3580,00 zł

Informacje o tej pozycji

Numer CAS:
58856-93-2
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00082157
Form:
powder with small lumps
Biological source:
Saccharomyces cerevisiae

347,00 zł

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biological source

Saccharomyces cerevisiae

Quality Segment

200

form

powder with small lumps

technique(s)

flow cytometry: suitable, tissue culture: suitable

color

off-white to light brown

storage temp.

2-8°C

Application

  • in flow cytometry
  • to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)

Zymosan A from Saccharomyces cerevisiae has been used:
  • as a positive control to determine the activation of complement cascade
  • for respiratory burst (RB) assay[1]
  • to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
  • a stimulating agent in Krebs-Ringer phosphate (KRP) medium
  • to induce thermal hyperalgesia in mice

Biochem/physiol Actions

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.
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YSC2YBDY1000
Zymosan A from Saccharomyces cerevisiae for inducing inflamatory response

Sigma-Aldrich

Z4250

Zymosan A from Saccharomyces cerevisiae

Yeast from Saccharomyces cerevisiae Type II

Sigma-Aldrich

YSC2

Yeast from Saccharomyces cerevisiae

Yeast Brewers Debittered, inactive

Sigma-Aldrich

YBD

Yeast Brewers

Select Yeast Extract powder, BioReagent, suitable for cell culture, suitable for insect cell culture

Sigma-Aldrich

Y1000

Select Yeast Extract

biological source

Saccharomyces cerevisiae

biological source

Saccharomyces cerevisiae

biological source

Saccharomyces cerevisiae

biological source

-

technique(s)

flow cytometry: suitable, tissue culture: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

form

powder with small lumps

form

powder or solid

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

off-white to light brown

color

-

color

-

color

-

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

1–9 of 9 Questions  

  1. How can I solubilize Zymosan? The information sheet does not provide this information. Can it be dissolved in water?

    1 answer

    1. This product is soluble in organic solvents as follows:
      - Chloroform: 100 µg/ml
      - Dimethyl sulfoxide: 200 µg/ml
      - Ethanol: 100 µg/ml.

      According to the 'Solubility/Solution Stability' section in the product information sheet, this product is not soluble in water but can be suspended uniformly in saline solution.

      Helpful?

  2. Is Z4250, Zymosan A from Saccharomyces cerevisiae, soluble in DMSO?

    1 answer

    1. Yes, this item is soluble in the following solvents:
      - Chloroform: 100 µg/ml
      - DMSO: 200 µg/ml
      - Ethanol: 100 µg/ml

      Helpful?

  3. How can Product Z4250, Zymosan be prepared for use in a properdin assay?

    1 answer

    1. Information on preparation of zymosan for use in a properdin assay, which includes boiling zymosan suspensions, is described on the product information sheet (under Documents, above).

      Helpful?

  4. How can I solubilize Zymosan, Product Z4250?

    1 answer

    1. Solubility information can be found in the product information sheet (under Documents, above) on our website.

      Helpful?

  5. Can Product Z4250, Zymosan suspension be autoclaved?

    1 answer

    1. We have no information as to whether zymosan suspensions can be autoclaved.  However, suspensions are stable to boiling conditions.

      Helpful?

  6. What is the particle size of Product Z4250, Zymosan?

    1 answer

    1. Sigma-Aldrich does not measure the particle size of zymosan. The average diameter of zymosan particles has been reported to be about 3 μm, as described on the product information sheet (under Documents, above), with the cited reference.

      Helpful?

  7. What is the source of the Zymosan in Product Z4250?

    1 answer

    1. This zymosan is prepared from single cell yeast.

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  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  9. What is the appearance of Product Z4250, Zymosan?

    1 answer

    1. The product is a powder which is described on the specification sheet.

      Helpful?

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