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SML0801

Palomid 529

Name: Palomid 529
Brand: SIGMA

≥98% (HPLC)

Synonim(y):

8-(1-Hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one, 8-(1-Hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-6H-dibenzo[b,d]pyran-6-one, P529, SG 00529

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₄H₂₂O₆

Numer CAS:

914913-88-5

Masa cząsteczkowa:

406.43

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Właściwości

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

[o]1c2c(c4c([c]1=O)cc(cc4)C(O)C)cc(c(c2)OCc3ccc(cc3)OC)OC

InChI

1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3

InChI key

YEAHTLOYHVWAKW-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor, which is unique in that it causes the dissociation of both the TORC1 and TORC2 complexes and inhibits both Akt and mTOR signaling. Palomid 529 has been shown to inhibit tumor growth, angiogenesis, and vascular permeability. Palomid 529 (P529) inhibited glioblastoma growth, penetrating the blood brain barrier with little affinity for ATP-binding cassette (ABC) drug efflux transporters ABCB1 and ABCG2. Palomid 529 has also shown promise as a possible treatment for macular degeneration and keloid disease.

Palomid 529 (P529) is a PI3K/Akt/mTPR inhibitor, which inhibits TORC1 and TORC2 complexes and both Akt and mTOR signaling.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Ta pozycja	SML0775	SML0230	SML1310
Sigma-Aldrich SML0801 Palomid 529	Sigma-Aldrich SML0775 PZ-II-029	Sigma-Aldrich SML0230 GW-803430	Sigma-Aldrich SML1310 NSC756093
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL, clear	solubility DMSO: 10 mg/mL, clear	solubility DMSO: ≥4 mg/mL at warmed to 60 °C	solubility DMSO: 10 mg/mL, clear
color white to beige	color white to light brown	color white to beige	color white to beige