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S9186
SIB 1757
≥99% (HPLC), crystalline
Synonim(y):
6-Methyl-2-(phenylazo)-3-pyridinol
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C12H11N3O
Numer CAS:
Masa cząsteczkowa:
213.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
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Pozwól nam pomócQuality Level
assay
≥99% (HPLC)
form
crystalline
color
red
SMILES string
Cc1ccc(O)c(\N=N\c2ccccc2)n1
InChI
1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+
InChI key
LOCPVWIREQIGNQ-CCEZHUSRSA-N
Gene Information
human ... GRM1(2911), GRM5(2915)
Application
SIB 1757 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.
Biochem/physiol Actions
SIB 1757 is a highly selective mGluR5 metabotropic glutamate receptor antagonist. It non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 Inhibition of mGlu5 receptor renders protection to neurons2 against methamphetamine-induced oxidative damage.3
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Ta pozycja | |||
|---|---|---|---|
| assay ≥99% (HPLC) | assay >99% | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form crystalline | form solid | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| color red | color - | color white to beige | color white to beige |
| Gene Information human ... GRM1(2911), GRM5(2915) | Gene Information human ... GRM1(2911), GRM5(2915) | Gene Information - | Gene Information - |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
V Bruno et al.
Neuropharmacology, 39(12), 2223-2230 (2000-09-07)
We have used potent and selective non-competitive antagonists of metabotropic glutamate receptor subtype 5 (mGlu5) -- 2-methyl-6-phenylethynylpyridine (MPEP), [6-methyl-2-(phenylazo)-3-pyridinol] (SIB-1757) and [(E)-2-methyl-6-(2-phenylethenyl)pyridine] (SIB-1893) - to examine whether endogenous activation of this particular metabotropic glutamate receptor subtype contributes to neuronal degeneration.
M A Varney et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 170-181 (1999-06-25)
Cell lines expressing the human metabotropic glutamate receptor subtype 5a (hmGluR5a) and hmGluR1b were used as targets in an automated high-throughput screening (HTS) system that measures changes in intracellular Ca2+ ([Ca2+]i) using fluorescence detection. This functional screen was used to
Giuseppe Battaglia et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(6), 2135-2141 (2002-03-16)
Methamphetamine (MA), a widely used drug of abuse, produces oxidative damage of nigrostriatal dopaminergic terminals. We examined the effect of subtype-selective ligands of metabotropic glutamate (mGlu) receptors on MA neurotoxicity in mice. MA (5 mg/kg, i.p.; injected three times, every
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| S9186-10MG | 04061832084756 |
| S9186-50MG | 04061832274188 |