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S0149
Streptolysin O from Streptococcus pyogenes
From Streptococcus pyogenes, Thiol-activated toxin, lyophilized powder
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 25000 units | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1230,00 zł 1045,50 zł |
Informacje o tej pozycji
Form:
lyophilized powder
Quality level:
1045,50 zł
Cena katalogowa1230,00 złZaoszczędź 15%Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
Streptolysin O from Streptococcus pyogenes, γ-irradiated
biological source
Streptococcus pyogenes
Quality Level
sterility
γ-irradiated
form
lyophilized powder
application(s)
cell analysis
storage temp.
2-8°C
Gene Information
Streptococcus pyogenes ... slo(900490)
Application
Permeabilizes membranes to permit cellular uptake of large or charged molecules.
Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.
Biochem/physiol Actions
Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.
Thiol-activated toxin that permeabilizes animal cell membranes..
Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.
Preparation Note
Prepared from S 5265
Other Notes
One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.
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Ta pozycja | |||
|---|---|---|---|
| form lyophilized powder | form lyophilized powder | form - | form lyophilized powder |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| application(s) cell analysis | application(s) - | application(s) - | application(s) - |
| Gene Information Streptococcus pyogenes ... slo(900490) | Gene Information Streptococcus pyogenes MGAS8232 ... slo(993428) | Gene Information - | Gene Information - |
| biological source Streptococcus pyogenes | biological source - | biological source - | biological source - |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Powiązane treści
Instructions
Extended exposure duration of cultured intestinal epithelial cell monolayers in characterizing hazardous and non-hazardous proteins
Zimmermann C, et al.
Food And Chemical Toxicology, 115(4), 451-459 (2018)
Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers
Vassilev B, et al.
The American Journal of Pathology, 185(4), 987-1000 (2015)
Streptolysin O derived from Streptococcus pyogenes inhibits RANKL-induced osteoclastogenesis through the NF-kappaB signaling pathway
Yi J, et al.
Molecular Medicine Reports (2018)
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| S0149-25KU | 04061836830083 |