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S5265

Sigma-Aldrich

Streptolysin O from Streptococcus pyogenes

lyophilized powder, Protein ~3 % by Lowry, 25,000-50,000 U/vial

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25000 UNITS
864,00 zł

864,00 zł

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25000 UNITS
864,00 zł

About This Item

Numer CAS:
98072-47-0
Numer WE:
308-500-3
Numer MDL:
MFCD00132389
Kod UNSPSC:
12352202
NACRES:
NA.85

864,00 zł

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Formularz

lyophilized powder

Poziom jakości

200

aktywność właściwa

25,000-50,000 U/vial

masa cząsteczkowa

native 69 kDa

skład

Protein, ~3% Lowry

warunki przechowywania

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

kolor

white

rozpuszczalność

H2O: soluble 1 mg/mL

spektrum działania antybiotyku

neoplastics

Tryb działania

cell membrane | interferes

temp. przechowywania

2-8°C

informacje o genach

Streptococcus pyogenes MGAS8232 ... slo(993428)

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Zastosowanie

Permeabilizes membranes to permit cellular uptake of large or charged molecules.
Streptolysin O is a toxin secreted by Streptococcus pyogenes and is a prototype member of poreforming bacterial cytolysins. It is used permeabilize cell membranes to permit cellular uptake of large or charged molecules. It is used to study macromolecule delivery[1]. It is a potential anticancer agent and is used to study suicide cancer gene therapy[1].
Used to create holes (reversible pores) in cholesterol-enriched plasma membranes of eukaryotic cells allowing selective permeabilization with molecules such as proteins (up to 100 kDa) and siRNAs.

Działania biochem./fizjol.

Streptolysin O possesses a single polypeptide chain with a molecular weight of f62 kDa. Streptolysin O binds to membrane cholesterol and oligomerizes to create a ring structure that consists of 45 to 50 units. The ring structure inserts into the membrane to make a large pore (25 to 30 nm), which DNA, RNA, peptides and proteins may pass[1]. It is thiol-activated. It is inhibited by allicin, an active component of garlic[2].
Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.
Thiol-activated toxin that permeabilizes animal cell membranes..

Opakowanie

25KU

Definicja jednostki

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

Postać fizyczna

Lyophilized powder containing Tris buffer salts, sodium azide, PMSF, and EDTA.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place
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Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H300 + H310 + H330,H315,H318,H411

Klasyfikacja zagrożeń

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Chen Chen et al.
Nanoscale, 10(11), 5154-5162 (2018-03-02)
Exosomes are small membrane vesicles secreted by a wide variety of cells. Studies have demonstrated that exosomal miRNAs can influence the biological processes of recipient cells. Therefore, direct imaging and tracking of exosomal miRNAs in living recipient cells are essential
Wan Seok Yang et al.
Molecular cancer therapeutics, 5(6), 1610-1619 (2006-07-05)
We cloned the streptolysin O gene from the Streptococcus pyogenes genome and tested the possibility of using it as an anticancer reagent. Transient transfection of the streptolysin O gene efficiently killed 293T cells after 12 hours of transfection as determined
Neurotransmitter interactions related to central dopamine neurons.
K G Lloyd
Essays in neurochemistry and neuropharmacology, 3, 129-207 (1978-01-01)
Stefanie Klar et al.
Journal of occupational medicine and toxicology (London, England), 16(1), 32-32 (2021-08-14)
Workers of agriculture and intensive life stock farming are exposed to highly contaminated workplaces. Bioaerosol exposures are suspected to trigger respiratory health effects of the workers. So far, risk evaluation of bioaerosols has been assessed through the infectivity of comprising
Mohsen Arzanlou et al.
Journal of medical microbiology, 59(Pt 9), 1044-1049 (2010-06-12)
Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated the effect of allicin and aqueous garlic extracts
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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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