This product is not soluble in aqueous solutions. Literature should be consulted for in vivo preparation methods.
Przejdź do
R8875
Rotenone
≥95% (HPLC), powder, NADH-CoQ reductase inhibitor
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
1 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 801,00 zł |
5 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1410,00 zł |
10 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2130,00 zł |
25 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 3230,00 zł 2745,50 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C23H22O6
Numer CAS:
Masa cząsteczkowa:
394.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
201-501-9
MDL number:
Beilstein/REAXYS Number:
6773081
Assay:
≥95%
801,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Rotenone, ≥95%
Quality Segment
assay
≥95%
bp
210-220 °C/0.5 mmHg (lit.)
mp
159-164 °C (lit.)
SMILES string
COc1cc2OCC3Oc4c5C[C@@H](Oc5ccc4C(=O)C3c2cc1OC)C(C)=C
InChI
1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
InChI key
JUVIOZPCNVVQFO-HBGVWJBISA-N
General description
Rotenone belongs to the retinoid family. It is naturally present in Leguminosa plants and is considered to be cytotoxic. It is commonly used as an insecticide and a pesticide.
Application
Rotenone has been used:
- to study its effect on cell proliferation
- to detect the production of cellular reactive oxygen species in isolated rat forebrain mitochondria
- to measure mitochondrial enzymatic activity
Biochem/physiol Actions
Inhibitor of mitochondrial electron transport.
Rotenone is an inhibitor of mitochondrial electron transport at nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone acts as a neurotoxic agent which can produce Parkinson-like condition to serve as an animal model for the study of etiology and interventions. The primary mechanism of action of rotenone is complex I inhibition, followed by the generation of oxidative stress and oxidative damage. Because rotenone is lipophilic, it readily penetrates the brain, where it attaches to and inhibits mitochondrial complex I of electron chain transport (ETC).
Preparation Note
This product is soluble in DMSO at 0.5 mg/ml. Other sources suggest it can be dissolved in DMSO up to 100 mM, however this has not been verified.
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Ta pozycja | |||
|---|---|---|---|
| assay ≥95% | assay - | assay ≥98% (HPLC) | assay - |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
| bp 210-220 °C/0.5 mmHg (lit.) | bp 210-220 °C/0.5 mmHg (lit.) | bp - | bp 210-220 °C/0.5 mmHg (lit.) |
| mp 159-164 °C (lit.) | mp 159-164 °C (lit.) | mp - | mp 159-164 °C (lit.) |
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signalword
Danger
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
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I dissolved this new product in 10 mL pure DMSO for 1 mM stock, as per protocol. But when diluted with DMEM/F12 or PBS for cell treatment, it forms white precipitate. How to fix this? Urgent help needed!!
1 answer-
Helpful?
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For how long can the product maintain stability in powder form at 4 °C or -80 °C?
1 answer-
The recommended storage temperature for this material is ambient or room temperature. Studies have not been conducted to evaluate the stability or shelf life impact of the product when stored at other temperatures. In the original sealed container, the compound is quite stable at room temperature. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/366/380/r8875pis.pdfHelpful?
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Can aliquots of rotenone resuspended in DMSO be stored at -20C?
1 answer-
The solution stability has not been determined. However, a similar product, 557368, notes that "following reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C".
Helpful?
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What is the solubility in other compounds ?
1 answer-
This product is tested for solubility at 50 mg/mL in chloroform. Rotenone is poorly soluble in water at approximately 0.25-0.50 uM. Other options include Ethanol and DMSO.
Ethanol: 5 mg/mL (higher concentrations may be achieved with heat and sonication)
DMSO: 50 mg/mLHelpful?
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What's the solubility in DMSO
1 answer-
This product is soluble in DMSO at 0.5 mg/ml. Other sources suggest it can be dissolved in DMSO up to 100 mM, however this has not been verified.
Helpful?
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