P7130

Puromycin aminonucleoside

Name: Puromycin aminonucleoside
Brand: SIGMA

Synonim(y):

3′-Amino-3′-deoxy-N⁶,N⁶-dimethyladenosine

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Wzór empiryczny (zapis Hilla):

C₁₂H₁₈N₆O₃

Numer CAS:

58-60-6

Masa cząsteczkowa:

294.31

UNSPSC Code:

51281912

NACRES:

NA.85

PubChem Substance ID:

24898823

EC Number:

200-388-3

Beilstein/REAXYS Number:

93902

MDL number:

MFCD00063462

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InChI key

RYSMHWILUNYBFW-VENHTOENSA-N

InChI

1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1

SMILES string

CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O

form

powder

solubility

H₂O: soluble 50 mg/mL

antibiotic activity spectrum

Gram-positive bacteria, neoplastics, parasites

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

300

Powiązane kategorie

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

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Ta pozycja	SBR00017	P8833	P9620
Sigma-Aldrich P7130 Puromycin aminonucleoside	Sigma-Aldrich SBR00017 Puromycin aminonucleoside Ready Made Solution	Sigma-Aldrich P8833 Puromycin dihydrochloride from Streptomyces alboniger	Sigma-Aldrich P9620 Puromycin dihydrochloride
mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes
antibiotic activity spectrum Gram-positive bacteria, parasites, neoplastics	antibiotic activity spectrum Gram-positive bacteria, neoplastics, parasites	antibiotic activity spectrum Gram-positive bacteria, neoplastics, parasites	antibiotic activity spectrum Gram-positive bacteria, neoplastics, parasites
Quality Level 300	Quality Level 200	Quality Level 300	Quality Level 300
form powder	form liquid	form powder	form solution
solubility H₂O: soluble 50 mg/mL	solubility -	solubility -	solubility H₂O: soluble 10 mg/mL
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C

General description

Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin. It is useful in nephrology research, like studies of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and nitrite (NOx) metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome are studied. Puromycin aminonucleoside-induced nephrosis in rats has been studied with respect to the production of reactive oxygen species during the acute phase. Puromycin aminonucleoside is used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.

Application

Puromycin aminonucleoside has been used:

as a selection marker for the infected cells for the transfection of lentivirus
as a component of fresh medium for transfection and infection assays
to subcutaneously induce puromycin aminonucleoside nephrosis to investigate the mRNA and protein levels of nephrin and podocin before the onset of proteinuria

Biochem/physiol Actions

Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes and is used to study glomerular function and morphology.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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signalword

Warning

pictograms

GHS08

hcodes

H373

Hazard Classifications

STOT RE 2

target_organs

Kidney

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

0000436781

0000445548

0000445550

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