P3371

Penfluridol

Name: Penfluridol
Brand: SIGMA
Price: 651.95 PLN

≥97% (HPLC), powder

Synonim(y):

1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

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50 MG

651,95 zł

Cena katalogowa767,00 złZaoszczędź 15%

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₈H₂₇ClF₅NO

Numer CAS:

26864-56-2

Masa cząsteczkowa:

523.97

NACRES:

NA.77

PubChem Substance ID:

329820171

UNSPSC Code:

12352200

EC Number:

248-074-5

MDL number:

MFCD00866714

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F

InChI

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

InChI key

MDLAAYDRRZXJIF-UHFFFAOYSA-N

Powiązane kategorie

Bioactive Small Molecule Inhibitors

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Ta pozycja	SML1809	P1793	SML1241
Sigma-Aldrich P3371 Penfluridol	Sigma-Aldrich SML1809 PPTN trifluoroacetate salt	Sigma-Aldrich P1793 Pimozide	Sigma-Aldrich SML1241 Pyr6
form powder	form powder	form powder	form powder
assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >20 mg/mL, H₂O: insoluble	solubility DMSO: 10 mg/mL, clear	solubility DMSO: 18 mg/mL(lit.), chloroform: 5 mg/mL, H₂O: insoluble(lit.)	solubility DMSO: 20 mg/mL, clear
color white	color white to beige	color -	color white to beige

Application

Penfluridol has been used as an antipsychotic agent:

to study its antimetastatic effect on triple-negative breast cancer cells[1]
to study its effects on the growth of glioblastoma cell lines[1],
to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)[2]

Biochem/physiol Actions

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis.[2] It also exhibits anticancer activity.[1]

T-type Ca²⁺channel blocker; antipsychotic

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Klasa składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certyfikaty analizy (CoA)

Lot/Batch Number

0000398879

0000390430

0000166335

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand.

M Mungthin et al.

The American journal of tropical medicine and hygiene, 60(3), 469-474 (1999-08-31)

The drug sensitivity characteristics and Plasmodium falciparum pfmdr1 status of five isolates of P. falciparum recently isolated from patients presenting for treatment from the Thailand/Myanmar border have been investigated. The aim of the study was to avoid the criticisms of

Preferential block of T-type calcium channels by neuroleptics in neural crest-derived rat and human C cell lines.

J J Enyeart et al.

Molecular pharmacology, 42(2), 364-372 (1992-08-01)

We have used the whole-cell version of the patch-clamp technique to analyze the inhibition of Ca2+ currents by antipsychotic agents in neural crest-derived rat and human thyroid C cell lines. Diphenylbutylpiperidine (DPBP) antipsychotics, including penfluridol and fluspirilene, potently and preferentially

Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis.

Suyash Srivastava et al.

International journal of molecular sciences, 21(3) (2020-01-26)

: Metastasis is considered a major burden in cancer, being responsible for more than 90% of cancer-related deaths. Tumor angiogenesis is one of the main processes that lead to tumor metastasis. Penfluridol is a classic and commonly used antipsychotic drug

Roles of intracellular and extracellular calcium in the kinetic profile of adrenocorticotropin secretion by perifused rat anterior pituitary cells. I. Corticotropin-releasing factor stimulation.

J G Won et al.

Endocrinology, 126(2), 849-857 (1990-02-01)

We examined the effects of removing extracellular Ca2+ (Ca2+e), depleting intracellular Ca2+ (Ca2+i), inhibiting Ca2(+)-dependent calmodulin, blocking voltage-sensitive Ca2+ channels, and combining Ca2+i depletion with exposure to glucocorticoid on the secretion of ACTH by perifused dispersed rat anterior pituitary cells

Neuroleptic malignant syndrome associated with abrupt withdrawal of anticholinergic agents.

B Spivak et al.

International clinical psychopharmacology, 11(3), 207-209 (1996-09-01)

Neuroleptic malignant syndrome (NMS) is a severe side-effect of neuroleptic treatment. It is usually related to hypodopaminergic activity. A young schizophrenic patient who developed a typical episode of NMS during abrupt withdrawal of long-acting neuroleptic combined with anticholinergic treatment is

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
P3371-50MG	04061834367765

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