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P0060

PLK1, active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonim(y):

STPK13

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Informacje o tej pozycji

NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
14-20 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

14-20 nmol/min·mg

mol wt

~70 kDa

UniProt accession no.

P53350

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PLK1(5347)

General description

PLK1 (polo like kinase 1) gene is mapped to human chromosome 16p12.2. It codes for the protein serine/threonine kinase.

Biochem/physiol Actions

PLK1 (polo like kinase 1) is predominantly involved in mitosis. It mediates the phosphorylation of cyclin B1/CDK1 (cyclin dependent kinase 1) complex, and activation of the anaphase promoting complex. PLK1 has anti-apoptotic function. Upregulation of gene is observed in different types of cancer, such as colorectal cancer and is regarded as an oncogene. PLK1 is involved in checkpoint recovery and adaptation following DNA damage.

Physical form

Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
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Ta pozycja
SRP0360K3393SRP5246
PLK1, active, His tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

P0060

PLK1, active, His tagged human

PLK1 Polo Box Domain active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sigma-Aldrich

SRP0360

PLK1 Polo Box Domain active human

PDK1, active, His tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

K3393

PDK1, active, His tagged human

PAK1, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5246

PAK1, active, GST tagged human

assay

≥70% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

Gene Information

human ... PLK1(5347)

Gene Information

human ... PLK1(5347)

Gene Information

human ... PDPK1(5170)

Gene Information

human ... PAK1(5058)

specific activity

14-20 nmol/min·mg

specific activity

-

specific activity

102-138 nmol/min·mg

specific activity

63-85 nmol/min·mg

form

buffered aqueous glycerol solution

form

aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Klasa składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Wykazy regulacyjne

Wykazy regulacyjne dotyczą głównie produktów chemicznych. Można w nich podawać ograniczoną liczbę informacji na temat produktów niechemicznych. Brak wpisu oznacza, że żaden ze składników nie znajduje się w wykazie. Użytkownik odpowiada za zagwarantowanie bezpiecznego i zgodnego z prawem stosowania produktu.

288-32-4

CAS No.

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
SLCR0357
SLCC9564
SLCB5131
SLBS1843V
SLBN4810V

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein a to mediate colon carcinoma cell differentiation and apoptosis.
Dasgupta N
Biochimica et Biophysica Acta (2017)
E A Nigg et al.
Experimental cell research, 229(2), 174-180 (1996-12-15)
During mitosis, the vertebrate cell nucleus undergoes profound changes in architecture. At the onset of mitosis, the nuclear envelope breaks down, the nuclear lamina is depolymerized, and interphase chromatin is condensed to chromosomes. Concomitantly, cytoplasmic microtubules are reorganized into a
Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.
Rouquier S
Disease Markers (2014)
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SKUNUMER GTIN
P0060-10UG04061837756450

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